Comparing and contrasting the use of nanoparticle-assisted drug-delivery of antidepressants to that of the gold standard
DOI:
https://doi.org/10.47611/jsr.v12i3.2025Keywords:
Nanoparticles, drug delivery, blood-brain barrier, intranasal, antidepressant, encapsulation, Solid-lipid-nanoparticle, alginate nanoparticle, controlled release, depressionAbstract
Nanoparticles (NP) are small-scale particles of elements at a scale that ranges between 1 to 100 nanometers. NP can be used to benefit drug delivery to the brain due to its ability to efficiently cross the blood-brain barrier (BBB). Depression is a widespread neuropsychiatric disorder with treatments that embody numerous flaws and shortcomings. A potential solution to this lack of treatment was pondered. NPs' ability to be implemented within antidepressants through encapsulation methods was investigated and the effects of NPs on the efficacy of the antidepressants were analyzed. Connections between the formulations of multiple NPs were made. Previous experiments and research regarding numerous NPs and how they were used to aid numerous types of antidepressants to treat various mental ailments were selected and analyzed thoroughly. From these findings, it was shown that various NP encapsulation and assistance methods can increase the efficacy of antidepressants, and potential implications of such findings were analyzed.
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