Post-Treatment Infection in Severe Burn Patients: A Comparative Review on Dermal Matrices
DOI:
https://doi.org/10.47611/jsr.v12i1.1905Keywords:
burns, dermal regeneration, infection, Novosorb Biodegradable Temporising Matrix (BTM), Integra Dermal Regeneration TemplateAbstract
Artificial dermal regeneration templates have been widely used in burn reconstruction surgery, and this allows subsequent skin graft to be taken more successfully. However, many clinical studies have noted instances of infection when testing the effectiveness of a specific template. This review aims to compare two common dermal regeneration templates that are very different in nature -- NovosorbÒ Biodegradable Temporising Matrix (BTM) and IntegraÒ Dermal Regeneration Template. Extensive literature search was conducted, and infection rates associated with each template were recorded. Based on the articles included, Integra has shown to be a more effective method and has resulted in lower infection rates. While current studies have begun to examine the use of dermal regeneration templates in additional settings, more long-term evaluations should be included in the future since wound contracture is a continuous process.
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Scott JR, Costa BA, Gibran NS, Engrav LH, Heimbach DH, Klein MB. Pediatric palm contact burns: a ten-year review. J Burn Care Res. 2008;29(4):614-618. doi:10.1097/BCR.0b013e31817db8f2
Gonzalez SR, Wolter KG, Yuen JC. Infectious Complications Associated with the Use of Integra: A Systematic Review of the Literature. Plast Reconstr Surg Glob Open. 2020 Jul; 8(7): e2869.
Published online 2020 Jul 15. doi: 10.1097/GOX.0000000000002869
Lo CH, Brown JN, Dantzer EJG, et al. Wound healing and dermal regeneration in severe burn patients treated with NovoSorb® Biodegradable Temporising Matrix: A prospective clinical study. Burns. 2022;48(3):529-538. doi:10.1016/j.burns.2021.07.014
Heimbach DM, Warden GD, Luterman A, et al. Multicenter postapproval clinical trial of Integra dermal regeneration template for burn treatment. J Burn Care Rehabil. 2003;24(1):42-48. doi:10.1097/00004630-200301000-00009
Chang DK, Louis MR, Gimenez A, Reece EM. The Basics of Integra Dermal Regeneration Template and its Expanding Clinical Applications. Semin Plast Surg. 2019;33(3):185-189. doi:10.1055/s-0039-1693401
Polynovo Pty Ltd. Novosorb BTM. https://usa.polynovo.com/ novosorb-btm/. [Accessed 12 Jan 2023].
Integra LifeSciences Corporation. https://www.integralife.com/file/general/1453796564.pdf. [Accessed 12 Jan 2023].
Cheshire PA, Herson MR, Cleland H, Akbarzadeh S. Artificial dermal templates: A comparative study of NovoSorb™ Biodegradable Temporising Matrix (BTM) and Integra(®) Dermal Regeneration Template (DRT). Burns. 2016;42(5):1088-1096. doi:10.1016/j.burns.2016.01.028
Bargues L, Boyer S, Leclerc T, Duhamel P, Bey E. Incidence et microbiologie des complications infectieuses lors d'utilisation de la peau artificielle Integra chez le brûlé [Incidence and microbiology of infectious complications with the use of artificial skin Integra in burns]. Ann Chir Plast Esthet. 2009;54(6):533-539. doi:10.1016/j.anplas.2008.10.013
Dantzer E, Braye FM. Reconstructive surgery using an artificial dermis (Integra): results with 39 grafts. Br J Plast Surg. 2001;54(8):659-664. doi:10.1054/bjps.2001.3684
Martínez L, Ros Z, López-Gutiérrez JC, et al. La dermis artificial (Integra) en cirugía reconstructiva pediátrica [Integra Artificial dermis in pediatric reconstructive surgery]. Cir Pediatr. 2002;15(3):97-100.
Lohana P, Hassan S, Watson SB. Integra™ in burns reconstruction: Our experience and report of an unusual immunological reaction. Ann Burns Fire Disasters. 2014;27(1):17-21.
Branski LK, Herndon DN, Pereira C, et al. Longitudinal assessment of Integra in primary burn management: a randomized pediatric clinical trial. Crit Care Med. 2007;35(11):2615-2623. doi:10.1097/01.CCM.0000285991.36698.E2
Kenneth W Larson, MD, Cindy L Austin, MS, Simon J Thompson, PhD. Treatment of a Full-Thickness Burn Injury With NovoSorb Biodegradable Temporizing Matrix and RECELL Autologous Skin Cell Suspension: A Case Series, Journal of Burn Care & Research. 2020; 41(1): 215–219. doi.org/10.1093/jbcr/irz179
X Liu, MD, PhD, S Velamuri, MD, M Hassouba, MD, D Hill, PharmD, W Hickerson, MD. 473 The Application of Biodegradable Temporizing Matrix in Burn Reconstructive Surgery: Preliminary Results of 36 cases, Journal of Burn Care & Research. 2019; 40(1): S209–S210. doi.org/10.1093/jbcr/irz013.367
John E. Greenwood, Bradley J. Schmitt, Marcus J.D. Wagstaff. Experience with a synthetic bilayer Biodegradable Temporising Matrix in significant burn injury, Burns. 2018; 2(1): 17-34. doi.org/10.1016/j.burnso.2017.08.001.
Kuang B, Pena G, Cowled P, et al. Use of Biodegradable Temporising Matrix (BTM) in the reconstruction of diabetic foot wounds: A pilot study. Scars, Burns & Healing. 2022;8. doi:10.1177/20595131221122272
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