Ferritin: Structure, Mechanism, Neuroferritinopathy in Human Body
DOI:
https://doi.org/10.47611/jsr.v11i4.1721Keywords:
Ferritin, Neuroferritinopathy, Rare DiseaseAbstract
When functioning well, ferritin plays a significant role in human body functioning as it helps to store and release iron ions to maintain human body stability. Otherwise, ferritin may fail in storing or release extra highly oxidative iron ions at different brain tissues, resulting in diseases such as neuroferritinopathy. Neuroferritinopathy is caused by gene mutations through two kinds of FTL genes. It can be inherited through genes and is autosomal dominant. Without paying efforts in tackling this diseases, more and more patients will suffer from its symptoms within generations. These symptoms will affect their daily physical movement and even personalities. Because neuroferritinopathy is caused by oxidative damage, anti-oxidation method therefore might be effective. Inheritance can be prevented by utilizing DNA polymerase or mismatch excision prepare enzymes for eggs and sperms.
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