Blue Zones: The Key to Neurodegenerative Disease Prevention
DOI:
https://doi.org/10.47611/jsrhs.v13i3.7171Keywords:
Neurodegenerative Disease, Blue Zones, Neurotoxins, Alzheimer's Disease, Prevention, Cognitive Health, Mortality RatesAbstract
Due to increased life expectancies and aging populations around the world, there has been a significant increase in the rate of neurodegenerative disease diagnosis in recent years. Although cases of neurodegenerative diseases have generally increased globally, there are still significant disparities, and some regions suffer substantially more from neurodegenerative diseases than others. The prevention of neurodegenerative diseases in these regions has rarely been discussed in literature. By examining a diverse set of primary sources describing how different lifestyle choices affect the development of neurodegenerative diseases, this research aims to explore the most effective methods of neurodegeneration prevention. Additionally, Blue Zones, areas of the world with significantly low rates of neurodegenerative diseases, have been specifically researched to determine how people in these regions are able to circumvent deterioration to their cognitive health. After intensive research into the impacts of common lifestyle habits on neurological health, a general blueprint for neurodegenerative disease prevention was created, outlining the activities and practices that individuals should take into consideration in their decision-making. This paper concluded that easily alterable factors such as healthy nutrition, consistent sleep, and reduced alcohol consumption can play a vital role in the prevention of neurodegenerative diseases. This research could allow areas with high rates of neurodegeneration to reduce deaths caused by cognitive deterioration by spreading knowledge of prevention methods. Overtime, this research could allow for a decrease in disparities in neurodegeneration around the world and potentially bring various populations closer to the cognitive prosperity that exists in Blue Zones.
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Bianchi, V. E., Herrera, P. F., & Laura, R. (2019). Effect of nutrition on neurodegenerative diseases. A systematic review. Nutritional Neuroscience, 24(10), 1–25. https://doi.org/10.1080/1028415x.2019.1681088
Bondy, S. C. (2016). Anthropogenic pollutants may increase the incidence of neurodegenerative disease in an aging population. Toxicology, 341-343, 41–46. https://doi.org/10.1016/j.tox.2016.01.007
Cracking the Code. (n.d.). Default. Retrieved April 26, 2024, from https://www.physiology.org/publications/news/the-physiologist-magazine/2023/may/cracking-the-code#:~:text=Of%20the%20more%20than%20600
Crews, F. (n.d.). Alcohol and Neurodegeneration. Retrieved April 26, 2024, from https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=5a7681fa3f17b0b65ee6c10784721e3a8138ae2f
Crichton, R. R., Dexter, D. T., & Ward, R. J. (2008, May). Metal based neurodegenerative diseases—From molecular mechanisms to therapeutic strategies. Science Direct; Coordination Chemistry Reviews. https://www.sciencedirect.com/science/article/abs/pii/S0010854507002548
Degenerative Nerve Diseases. (n.d.). Medlineplus.gov. https://medlineplus.gov/degenerativenervediseases.html#:~:text=Many%20of%20these%20diseases%20are
Gardener, H., & Caunca, M. R. (2018). Mediterranean Diet in Preventing Neurodegenerative Diseases. Current Nutrition Reports, 7(1), 10–20. https://doi.org/10.1007/s13668-018-0222-5
Getzzg. (2023, November 29). Global, regional, and national burden of neurological disorders in 204 countries and territories worldwide. JOGH. https://jogh.org/2023/jogh-13-04160.
Giacoppo, S., Galuppo, M., Rocco Salvatore Calabrò, Giangaetano D'Aleo, Marra, A., Sessa, E., Daniel Giuseppe Bua, Angela Giorgia Potortì, Dugo, G., Placido Bramanti, & Emanuela Mazzon. (2014). Heavy Metals and Neurodegenerative Diseases: An Observational Study. Biological Trace Element Research, 161(2), 151–160. https://doi.org/10.1007/s12011-014-0094-5
Hassanzadeh, E. (2023, October 16). Longevity-prone geographic “Blue Zones” hold clues for how to live longer, healthier lives - CBS Minnesota. Www.cbsnews.com. https://www.cbsnews.com/minnesota/news/longevity-prone-geographic-blue-zones-hold-clues-for-how-to-live-longer-healthier-lives/
Liu, T., Gatto, N. M., Chen, Z., Qiu, H., Lee, G., Duerksen-Hughes, P., Fraser, G., & Wang, C. (2020). Vegetarian diets, circulating miRNA expression and healthspan in subjects living in the Blue Zone. Precision Clinical Medicine, 3(4). https://doi.org/10.1093/pcmedi/pbaa037
Marques-Aleixo, I., Beleza, J., Sampaio, A., Stevanović, J., Coxito, P., Gonçalves, I., Ascensão, A., & Magalhães, J. (2021). Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases. Antioxidants & Redox Signaling, 34(8), 674–693. https://doi.org/10.1089/ars.2020.8075
Martínez Leo, E. E., & Segura Campos, M. R. (2019). Ultra-Processed Diet- Gut Microbiota- and Its Role in Neurodegenerative Diseases. Nutrition, 71, 110609. https://doi.org/10.1016/j.nut.2019.110609
News. (n.d.). UC Davis Health’s Alzheimer’s collaborations yielding early results locally. News. Retrieved April 26, 2024, from https://health.ucdavis.edu/news/headlines/uc-davis-healths-alzheimers-collaborations-yielding-early-results-locally-/2023/08
Perneczky, R. (2019). Dementia prevention and reserve against neurodegenerative disease. Disease-Modifying Therapy in Dementia, 21(1), 53–60. https://doi.org/10.31887/dcns.2019.21.1/rperneczky2
Rafael, D. (n.d.). Blue zones, Dementia and Alzheimer’s Disease. Scholarworks.calstate.edu. Retrieved April 26, 2024, from https://scholarworks.calstate.edu/concern/theses/8k71nn84j?locale=it
Rizzi, L., Rosset, I., & Roriz-Cruz, M. (2014). Global Epidemiology of Dementia: Alzheimer’s and Vascular Types. BioMed Research International, 2014, 1–8. https://doi.org/10.1155/2014/908915
Table 19 Leading Causes of Death for Selected Years, Texas Residents | Texas DSHS. (n.d.). Www.dshs.texas.gov. https://www.dshs.texas.gov/vital-statistics-data/vital-statistics-annual-reports/list-tables-and-references/table-19-leading-causes-death-selected-years-texas-residents
Tschudi, F.-M., Zurich, M.-G., Boschat, C., Corbaz, A., & Honegger, P. (2006, April 1). Involvement of Environmental Mercury and Lead in the Etiology of Neurodegenerative Diseases. De Gruyter; De Gruyter. https://www.degruyter.com/document/doi/10.1515/REVEH.2006.21.2.105/html
Videnovic, A., & Abbott, S. (2016). Chronic sleep disturbance and neural injury: links to neurodegenerative disease. Nature and Science of Sleep, 55. https://doi.org/10.2147/nss.s78947
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