Exploring the Impact of Fatty Acids on Ovarian Cancer Progression

Abstract

Ovarian cancer (OC) stands as a formidable challenge in women's health, constituting a significant portion of gynecological-related deaths. The aggressive nature of epithelial ovarian cancer (EOC) manifests as a major hindrance to effective treatment. This study delves into the complex interplay between fatty acid stimuli, cellular signaling pathways, and subsequent cellular responses in the context of ovarian cancer, employing mouse ovarian cancer cell lines ID8 with distinct genetic backgrounds—those harboring BRCA2/p53 mutations and those with solely p53 mutations. Despite the well-established role of fatty acids in cancer cell growth, invasion, and metastasis, the intricate dynamics of how these molecules modulate signaling pathways and influence cellular outcomes, particularly in ovarian cancer with specific genetic mutations, remain less explored. In this context, the study aims to elucidate the differential responses observed in cell signaling activation and cell proliferation, shedding light on the unique sensitivity of ID8 cells with both p53 and BRCA2 mutations to odd chain fatty acids. Additionally, the investigation underscores the correlation between fatty acid types and lipid accumulation, offering valuable insights into the potential mechanisms driving ovarian cancer aggressiveness. These findings emphasize the importance of considering genetic backgrounds in tailoring therapeutic strategies, paving the way for more effective and personalized approaches in the treatment of ovarian cancer.