Effect of Long-term Oral Administration of Different Dosages of Caffeine on Anesthetic Emerging Time

Abstract

This paper aims to investigate the effect of prolonged oral ingestion of different doses of caffeine on anesthetic emergence time. In our experiment, eighteen male mice were selected and randomly divided into three groups of six mice, each according to the concentration of caffeine administered: a high-concentration caffeine group, a low-concentration caffeine group, and a blank control group. Mice were anesthetized with isoflurane and Zoletil 50, and the time of emergence was recorded for both anesthesia and the time of entry into anesthesia was recorded for Zoletil 50 anesthesia. Twenty-four hours after the anesthesia experiments, the mice were subjected to Morris water maze experiments, visual station experiments, hidden station experiments, and spatial exploration experiments. The results showed that both high-dose and low-dose coffee ig accelerated isoflurane and Zoletil 50 anesthesia emerging, with the high-dose being statistically more significant for the acceleration of anesthesia emerging. Prolonged oral coffee administration did not affect the time to enter anesthesia. Long-term oral coffee administration enhanced spatial exploration and spatial learning memory after anesthesia.