Analyzing Single Nucleotide Polymorphisms and Their Chromosomal Distribution to Unravel the Genetic Landscape of Melanoma
DOI:
https://doi.org/10.47611/jsrhs.v13i1.6297Keywords:
Melanoma, Single Nucleotide Polymorphisms (SNPs), Genomic Variants, Personalized Medicine, Therapeutic Targets, Early Detection.Abstract
Melanoma, a malignant skin cancer, continues to pose significant challenges in early detection, optimal treatment strategies, and understanding its etiology. This study aimed to elucidate the complex genetic landscape of melanoma by analyzing 2,641 Single Nucleotide Polymorphisms (SNPs) across 18 genomic variant categories within a melanoma cohort. The analysis revealed diverse genetic variations, including Missense and Frameshift Variants, with a significant number of unknown variants that require further exploration. A significant association (p < 0.05) was found between the identified variants and the melanoma cohort. The study's findings underscore the heterogeneous nature of melanoma and emphasize the potential need for personalized therapeutic approaches. This comprehensive study contributes valuable insights into melanoma's genetic landscape and holds promise for future interventions and personalized prevention and treatment strategies.
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