3-D Printed Scaffolds, the Building Blocks to a New Way to Repair the Eardrum
DOI:
https://doi.org/10.47611/jsrhs.v13i1.6281Keywords:
3D printing, tympanic membrane, eardrum perforations, scaffolding, biofabrication, artificial materialsAbstract
In nature, when the eardrum is perforated, it is common for the body to heal itself with time. However, in some cases, surgery or grafting is required to repair the membrane. 3-D printing tympanic membrane (TM) scaffolds is a developing field (with great potential) that aims to create a streamlined method to facilitate the repopulation of TM cells and collagen on a damaged TM. Here we analyze and evaluate the different materials, methods of printing, shapes, and resonance that bioengineering researchers tested to optimize the efficacy of the 3-D printed scaffold. Surprisingly, the scaffolds have proven to be not only more structurally consistent, but also structurally stronger. We also suggest that clinical testing on an organic specimen and more developments in synthesizing all the different techniques for these 3-D printed scaffolds would be necessary. Ultimately, the research reviewed here demonstrates that 3-D printed scaffolding is a promising treatment for those with tympanic perforations that may even overtake tympanoplasty or autologous grafting as a more accessible and consistent alternative to TM repair. In the bigger picture, scaffolding could be used for other body parts in their repairs.
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Lipson, H., & Kurman, M. (2013). Fabricated: The new world of 3D printing. John Wiley & Sons.
Nawrat, A. (2018). 3D printing in the medical field: four major applications revolutionising the industry. Verdict Medical Devices.
Fuchs, J. C., & Tucker, A. S. (2015). Development and integration of the ear. Current Topics in Developmental Biology, 115, 213-232.
Lin, Y. K., & Liu, D. C. (2006). Comparison of physical–chemical properties of type I collagen from different species. Food Chemistry, 99(2), 244-251. https://doi.org/10.1016/j.foodchem.2005.06.053
Stenfeldt, K., Johansson, C., & Hellström, S. (2006). The collagen structure of the tympanic membrane: collagen types I, II, and III in the healthy tympanic membrane, during healing of a perforation, and during infection. Archives of Otolaryngology–Head & Neck Surgery, 132(3), 293-298.
doi: 10.1001/archotol.132.3.293.
Bogle, J. M. (2022). Mayo Clinic on Hearing and Balance. Mayo Clinic Press; 3rd edition.
Mota, C., Danti, S., D’Alessandro, D., Trombi, L., Ricci, C., Puppi, D., & Berrettini, S. (2015). Multiscale fabrication of biomimetic scaffolds for tympanic membrane tissue engineering. Biofabrication, 7(2), 025005.
doi: 10.1088/1758-5090/7/2/025005.
Miyamoto, R. T. (2022). Traumatic perforation of the tympanic membrane. Merck Manuals Professional Version.
“Middle-Ear Infection in Adults,” Johns Hopkins Medicine, https://www.hopkinsmedicine.org/health/conditions-and-diseases/otitis-media-middle-ear-infection-in-adults.
“Ear Infections in Babies and Toddlers.” Johns Hopkins Medicine, https://www.hopkinsmedicine.org/health/conditions-and-diseases/ear-infections-in-babies-and-toddlers.
Dolhi, N., Weimer, A. D. (2023). Tympanic Membrane Perforation. In: StatPearls. Treasure Island (FL): StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK557887/
Kozin, E. D., Black, N. L., Cheng, J. T., Cotler, M. J., McKenna, M. J., Lee, D. J., Lewis, J. A., Rosowski, J. J. and Remenschneider, A. K. (2016). Design, fabrication, and in vitro testing of novel three-dimensionally printed tympanic membrane grafts. Hearing Research, 340, 191-203.
doi: 10.1016/j.heares.2016.03.005.
Akdere, M., & Schneiders, T. (2021). Modeling of the electrospinning process. In Advances in Modeling and Simulation in Textile Engineering (pp. 237-253). Woodhead Publishing.
Gibson, I., Rosen, D. W., Stucker, B., Khorasani, M., Rosen, D., Stucker, B., & Khorasani, M. (2021). Additive manufacturing technologies (Vol. 17, pp. 160-186). Cham, Switzerland: Springer.
Ullah, I., Subbarao, R. B., & Rho, G. J. (2015). Human mesenchymal stem cells-current trends and future prospective. Bioscience Reports, 35(2), e00191.
Anand, S., Stoppe, T., Lucena, M., Rademakers, T., Neudert, M., Danti, S., ... & Mota, C. (2021). Mimicking the human tympanic membrane: the significance of scaffold geometry. Advanced Healthcare Materials, 10(11), 2002082.
doi: 10.1002/adhm.202002082.
Ilhan, E., Ulag, S., Sahin, A., Yilmaz, B. K., Ekren, N., Kilic, O., ... & Gunduz, O. (2021). Fabrication of tissue-engineered tympanic membrane patches using 3D-Printing technology. Journal of the Mechanical Behavior of Biomedical Materials, 114, 104219.
doi: 10.1016/j.jmbbm.2020.104219.
Yao, X., Teh, B. M., Li, H., Hu, Y., Huang, J., Lv, C., ... & Shen, Y. (2021). Acellular collagen scaffold with basic fibroblast growth factor for repair of traumatic tympanic membrane perforation in a rat model. Otolaryngology–Head and Neck Surgery, 164(2), 381-390.
doi: 10.1177/0194599820938345.
Hu, H., Chen, J., Li, S., Xu, T., & Li, Y. (2023). 3D printing technology and applied materials in eardrum regeneration. Journal of Biomaterials Science, Polymer Edition, 34(7), 950-985.
von Witzleben, M., Stoppe, T., Zeinalova, A., Chen, Z., Ahlfeld, T., Bornitz, M., ... & Gelinsky, M. (2023). Multimodal additive manufacturing of biomimetic tympanic membrane replacements with near tissue-like acousto-mechanical and biological properties. Acta Biomaterialia, 170, 124-141.
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Copyright (c) 2024 Daniel Kim; Asher Kim, Mohammad Rostami
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