Increasing the Solubility of Glipizide Through Changes in Molecular Structure
DOI:
https://doi.org/10.47611/jsrhs.v13i1.6083Keywords:
biochemistry, drugs, molecular structure, diabetes drugsAbstract
Glipizide is a drug that is used in the treatment of type 2 diabetes mellitus, which accounts for 90% of all cases of diabetes mellitus. Glipizide is a drug with poor solubility in water and therefore is not the best agent to be utilized in treating this condition. In this paper, new derivatives of glipizide were created to have a version of the molecule with higher solubility and more bioavailability as a result. Therefore, the objective of this investigation is to improve the solubility of glipizide in water. With the new derivatives found, glipizide can become more water soluble and therefore more easily accessible to the body to be used in the treatment of diabetes. Derivatives 1, 3, 4, and 5 have logP values of -0.23, 0.85, -0.93, and 0.01 respectively. These are much lower than the logP value (1.55) of glipizide. The derivatives are more bioavailable and therefore will require a smaller dose to have the same effect.
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