Identifying Locations for Transcranial Magnetic Stimulation Coil Placement For Deep Brain Structures
DOI:
https://doi.org/10.47611/jsrhs.v12i4.5924Keywords:
Transcranial Magnetic Stimulation, Brain Stimulation, Neuroscience, Unsupervised LearningAbstract
Stimulation of deep brain structures with transcranial magnetic stimulation (TMS) is the premier mode of non-invasive brain stimulation (NIBS). Currently, there is little support for the application of TMS in modulating deeper brain structures. This study validates the use of TMS for a set of 8 deep brain structures shown to alleviate symptoms of certain conditions when stimulated. 200 sets of T1-weighted and T2-weighted MRIs were processed using the SimNIBS headreco pipeline. Then, 200 TMS optimization simulations were run for each brain structure, which generated 200 3D coordinates for each structure representing the best TMS coil placement locations on the scalp for stimulation. This data was analyzed using K-means and agglomerative clustering methods to find the overall best coil placement locations. Overall, this study validates the use of TMS to stimulate these brain structures and finds the optimal parameters for stimulation.
Downloads
References or Bibliography
Adolfo Ramirez-Zamora, M. D. (2018, March 1). Pallidal or subthalamic nucleus deep brain stimulation for parkinson disease. JAMA Neurology. Retrieved October 28,
, from
https://jamanetwork.com/journals/jamaneurology/article-abstract/2670447.
authors, A., Tendler, A., & Additional informationFundingThis paper was funded by Brainsway Ltd. (n.d.). Deep transcranial magnetic stimulation (dtms) – beyond
depression. Taylor & Francis. Retrieved October 28, 2021, from
https://www.tandfonline.com/doi/full/10.1080/17434440.2016.1233812.
Børretzen, M. N., Bjerknes, S., Sæhle, T., Skjelland, M., Skogseid, I. M., Toft, M., & Dietrichs, E. (2014, June 5). Long-term follow-up of thalamic deep brain stimulation for essential tremor – patient satisfaction and mortality. BMC
Neurology. Retrieved October 28, 2021, from
https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-14-120.
Benabid AL;Krack PP;Benazzouz A;Limousin P;Koudsie A;Pollak P; (n.d.). Deep brain stimulation of the subthalamic nucleus for parkinson's disease: Methodologic aspects and clinical criteria. Neurology. Retrieved October 28, 2021, from
https://pubmed.ncbi.nlm.nih.gov/11188974/.
Boccard, S. G. J., Prangnell, S. J., Pycroft, L., Cheeran, B., Moir, L., Pereira, E. A. C., Fitzgerald, J. J., Green, A. L., & Aziz, T. Z. (2017, July 11). Long-term results of deep brain stimulation of the anterior cingulate cortex for neuropathic pain. World
Neurosurgery. Retrieved October 28, 2021, from
https://www.sciencedirect.com/science/article/abs/pii/S1878875017310811.
Bove, F., Mulas, D., Cavallieri, F., Castrioto, A., Chabardès, S., Meoni, S., Schmitt, E.,
Bichon, A., Stasio, E. D., Kistner, A., Pélissier, P., Chevrier, E., Seigneuret, E.,
Krack, P., Fraix, V., & Moro, E. (2021, July 20). Long-term outcomes (15 years) after subthalamic nucleus deep brain stimulation in patients with parkinson
disease. Neurology. Retrieved October 28, 2021, from
https://n.neurology.org/content/97/3/e254.
D;, F. K. A. T.-R. (n.d.). Deep brain stimulation of globus pallidus interna, subthalamic nucleus, and pedunculopontine nucleus for parkinson's disease: Which target? Parkinsonism & related disorders. Retrieved October 28, 2021, from
https://pubmed.ncbi.nlm.nih.gov/22166422/.
Daneshzand, M., Makarov, S. N., de Lara, L. I. N., Guerin, B., McNab, J., Rosen, B. R., Hämäläinen, M. S., Raij, T., & Nummenmaa, A. (2021, August 15). Rapid
computation of TMS-induced E-fields using a dipole-based magnetic stimulation
profile approach. NeuroImage. Retrieved October 28, 2021, from
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353625/.
Deng, Z.-D., Lisanby, S. H., & Peterchev, A. V. (2013, January). Electric field depth-focality tradeoff in transcranial magnetic stimulation: Simulation comparison of 50 coil designs. Brain stimulation. Retrieved October 28, 2021, from
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568257/.
Fricke, C., Duesmann, C., Woost, T. B., von Hofen-Hohloch, J., Rumpf, J.-J., Weise, D., & Classen, J. (1AD, January 1). Dual-site transcranial magnetic stimulation for the treatment of parkinson's disease. Frontiers. Retrieved October 28, 2021, from
https://www.frontiersin.org/articles/10.3389/fneur.2019.00174/full.
Gomez, L. J., Dannhauer, M., & Peterchev, A. V. (2020, December 30). Fast
computational optimization of TMS coil placement for individualized electric field
targeting. NeuroImage. Retrieved October 28, 2021, from
https://www.sciencedirect.com/science/article/pii/S1053811920311812?via%3Dihu b.
Greenberg, B. D., Gabriels, L. A., Malone, D. A., Rezai, A. R., Friehs, G. M., Okun, M. S.,
Shapira, N. A., Foote, K. D., Cosyns, P. R., Kubu, C. S., Malloy, P. F., Salloway, S.
P., Giftakis, J. E., Rise, M. T., Machado, A. G., Baker, K. B., Stypulkowski, P. H., Goodman, W. K., Rasmussen, S. A., & Nuttin, B. J. (2008, May 20). Deep brain stimulation of the ventral internal capsule/ventral striatum for
obsessive-compulsive disorder: Worldwide experience. Nature News. Retrieved
October 28, 2021, from
https://www.nature.com/articles/mp200855?error=cookies_not_supported&code=+
bc085581-b166-4dd0-a994-4ab3ef7f3fc9.
Hamel, W., Fietzek, U., Morsnowski, A., Schrader, B., Herzog, J., Weinert, D., Pfister, G., Müller, D., Volkmann, J., Deuschl, G., & Mehdorn, H. M. (2003, August 1). Deep brain stimulation of the subthalamic nucleus in parkinson's disease: Evaluation of active electrode contacts. Journal of Neurology, Neurosurgery & Psychiatry. Retrieved October 28, 2021, from https://jnnp.bmj.com/content/74/8/1036.
Jin H;Li W;Dong C;Wu J;Zhao W;Zhao Z;Ma L;Ma F;Chen Y;Liu Q; (n.d.). Hippocampal deep brain stimulation in nonlesional refractory Mesial Temporal Lobe epilepsy.
Seizure. Retrieved October 28, 2021, from
https://pubmed.ncbi.nlm.nih.gov/26908151/.
Koek, R. J., Langevin, J.-P., Krahl, S. E., Kosoyan, H. J., Schwartz, H. N., Chen, J. W. Y., Melrose, R., Mandelkern, M. J., & Sultzer, D. (2014, September 10). Deep brain stimulation of the basolateral amygdala for treatment-refractory combat post-traumatic stress disorder (PTSD): Study protocol for a pilot randomized controlled trial with blinded, staggered onset of stimulation. Trials. Retrieved October 28, 2021, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168122/.
Kreuzer, P. M., Lehner, A., Schlee, W., Vielsmeier, V., Schecklmann, M., Poeppl, T. B., Landgrebe, M., Rupprecht, R., & Langguth, B. (2015, December 15). Combined
RTMS treatment targeting the anterior cingulate and the temporal cortex for the treatment of chronic tinnitus. Nature News. Retrieved October 28, 2021, from
https://www.nature.com/articles/srep18028?error=cookies_not_supported&code=+ +c3bb5eeb-f913-4820-96b1-ced614cc469c.
Leoutsakos JS;Yan H;Anderson WS;Asaad WF;Baltuch G;Burke A;Chakravarty MM;Drake KE;Foote KD;Fosdick L;Giacobbe P;Mari Z;McAndrews MP;Munro CA;Oh ES;Okun MS;Pendergrass JC;Ponce FA;Rosenberg PB;Sabbagh MN;Salloway S;Tang-Wai DF;Targum SD;Wolk D;Lozano AM;S. (n.d.). Deep
brain stimulation targeting the fornix for mild alzheimer dementia (the advance trial): A two year follow-up including results of delayed activation. Journal of
Alzheimer's disease : JAD. Retrieved October 28, 2021, from
https://pubmed.ncbi.nlm.nih.gov/29914028/.
Lv, Q., Du, A., Wei, W., Li, Y., Liu, G., & Wang, X. P. (1AD, January 1). Deep Brain Stimulation: A potential treatment for dementia in alzheimer's disease (AD) and parkinson's disease dementia (PDD). Frontiers. Retrieved October 28, 2021, from
https://www.frontiersin.org/articles/10.3389/fnins.2018.00360/full.
Navarro de Lara, L. I., Daneshzand, M., Mascarenas, A., Paulson, D., Pratt, K., Okada, Y., Raij, T., Makarov, S. N., & Nummenmaa, A. (2021, January 1). A 3-axis coil design for multichannel TMS arrays. NeuroImage. Retrieved October 28, 2021, from
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837414/.
Nielsen, J. D., Madsen, K. H., Puonti, O., Siebner, H. R., Bauer, C., Madsen, C. G., Saturnino, G. B., & Thielscher, A. (2018, March 12). Automatic skull segmentation from MR images for realistic volume conductor models of the head: Assessment of the state-of-the-art. NeuroImage. Retrieved October 28, 2021, from
https://www.sciencedirect.com/science/article/abs/pii/S1053811918301800?via%3 Dihub.
P;, P. M. B. G. Z. L. B. (n.d.). Hippocampal deep brain stimulation: Persistent seizure control after bilateral extra-cranial electrode fracture. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of
Clinical Neurophysiology. Retrieved October 28, 2021, from
https://pubmed.ncbi.nlm.nih.gov/29756178/#:~:text=Hippocampal%20deep%20b
rain%20stimulation%20(DBS,a%20bilateral%20hippocampal%20DBS%20devic e.
Russo, J. F., & Sheth, S. A. (2015, June 1). Deep brain stimulation of the dorsal anterior cingulate cortex for the treatment of chronic neuropathic pain. focus. Retrieved
October 28, 2021, from
https://thejns.org/focus/view/journals/neurosurg-focus/38/6/article-pE11.xml.
Samoudi, A. M., Tanghe, E., Martens, L., & Joseph, W. (2018, June 5). Deep transcranial magnetic stimulation: Improved coil design and assessment of the induced fields using MIDA model. BioMed Research International. Retrieved October 28, 2021,
from https://www.hindawi.com/journals/bmri/2018/7061420/.
Schutter, D. J. L. G., & van Honk, J. (2005, March). A framework for targeting alternative brain regions with repetitive transcranial magnetic stimulation in the treatment of depression. Journal of psychiatry & neuroscience : JPN. Retrieved October 28, 2021, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC551160/.
Sims-Williams, H., Matthews, J. C., Talbot, P. S., Love-Jones, S., Brooks, J. C., Patel, N. K., & Pickering, A. E. (2017, February 1). Deep brain stimulation of the periaqueductal gray releases endogenous opioids in humans. NeuroImage.
Retrieved October 28, 2021, from
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312788/#:~:text=Deep%20brain %20stimulation%20(DBS)%20of,positron%20emission%20tomography%20(PET
).
Sturm, V., Fricke, O., Buehrle, C. P., Lenartz, D., Maarouf, M., Treuer, H., Mai, J. K., & Lehmkuhl, G. (1AD, January 1). DBS in the basolateral amygdala improves symptoms of autism and related self-injurious behavior: A case report and hypothesis on the pathogenesis of the disorder. Frontiers. Retrieved October 28, 2021, from https://www.frontiersin.org/articles/10.3389/fnhum.2012.00341/full.
Tanaka, R., Ansari, A., Kajita, Y., Yamada, Y., Kawase, T., & Kato, Y. (2019). Staged deep brain stimulation of ventral intermediate nucleus of the thalamus for suppression of essential tremors. Asian journal of neurosurgery. Retrieved October 28, 2021, from
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703004/.
Tao, Q., Yang, Y., Yu, H., Fan, L., Luan, S., Zhang, L., Zhao, H., Lv, L., Jiang, T., & Song, X. (2020, April 3). Anatomical connectivity-based strategy for targeting transcranial magnetic stimulation as antidepressant therapy. Frontiers in
psychiatry. Retrieved October 28, 2021, from
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145890/.
Tendler, A., Roth, Y., Barnea-Ygael, N., & Zangen, A. (2017, January 23). How to use the H1 deep transcranial magnetic stimulation coil for conditions other than
depression. Journal of visualized experiments : JoVE. Retrieved October 28, 2021,
from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352287/.
Theodore, W. H. (2003, November). Transcranial magnetic stimulation in epilepsy.
Epilepsy currents. Retrieved October 28, 2021, from
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC321221/.
Weise, K., Numssen, O., Thielscher, A., Hartwigsen, G., & Knösche, T. R. (2019, December 23). A novel approach to localize cortical TMS effects. NeuroImage.
Retrieved October 28, 2021, from
https://www.sciencedirect.com/science/article/pii/S1053811919310778?via%3Dihu b.
Yazdanian, H., Saturnino, G. B., Thielscher, A., & Knudsen, K. (2020, March 19). Fast evaluation of the BIOT-Savart integral using FFT for electrical conductivity imaging. Journal of Computational Physics. Retrieved October 28, 2021, from
https://www.sciencedirect.com/science/article/pii/S0021999120301820?via%3Dihu b.
Zhang, C., Li, D., Jin, H., Zeljic, K., & Sun, B. (2017, October). Target-specific deep brain
stimulation of the ventral capsule/ventral striatum for the treatment of
neuropsychiatric disease. Annals of translational medicine. Retrieved October 28, 2021, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673773/.
Zibman, S., Pell, G. S., Barnea-Ygael, N., Roth, Y., & Zangen, A. (2019, July 5). Application of transcranial magnetic stimulation for major depression: Coil design
and neuroanatomical variability considerations. European Neuropsychopharmacology. Retrieved October 28, 2021, from
https://www.sciencedirect.com/science/article/pii/S0924977X19302676.
Published
How to Cite
Issue
Section
Copyright (c) 2023 Tanush Paradeshi; Dr. Liljeholm
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Copyright holder(s) granted JSR a perpetual, non-exclusive license to distriute & display this article.