The Beneficial Effects of C-peptide for Diabetic Encephalopathy
DOI:
https://doi.org/10.47611/jsrhs.v12i4.5837Keywords:
Diabetes, Prevention, Diabetic Encephalopathy, C-peptideAbstract
Diabetes is a disease that millions of people globally are affected by its symptoms along with its complications. Even with treatment plans such as insulin injections or pumps, diabetes remains a widescale, worldwide problem. If a patient is diagnosed with diabetes, they can experience heart and kidney disease, vision dysfunction, oral health deterioration, and nerve damage. However, as recent studies show, a peptide, which was originally used as an early detection tool for diabetes, has exhibited many remunerative characteristics that may benefit diabetes and other complications caused by the disease. More specifically, diabetic encephalopathy, a disease known for cognitive impairment and damage to the nervous system, could improve with the help of C-peptide. With C-peptide’s therapeutic effects of improved blood flow, nerve cell regeneration and repair, anti-inflammatory responses, and a decrease in experiencing a stroke, C-peptide has many profitable advantages for treating complications of diabetes related to the deterioration of the nervous system. In this study, the paper will discuss the latest findings on the effects of C-peptide on diabetic encephalopathy, the disadvantages and limits with the use of the substance, areas of uncertainty, and how the new discovery may alter the future. Researchers hope with this new discovery there will be further research done to figure out how C-peptide may help other diseases in the body or may act as a potential cure for diabetes. C-peptide may become a more common and effective candidate for treatment options of diabetes.
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Adhikari, P., Chowta, N., Shenoy, A., D′Souza, S., & Chowta, M. (2010). Serum C peptide level and renal function in diabetes mellitus. Indian Journal of Nephrology, 20(1), 25. https://doi.org/10.4103/0971-4065.62093
Bhagavan, N. V., & Ha, C.-E. (2015). Perturbations of Energy Metabolism. Www.sciencedirect.com. https://www.sciencedirect.com/topics/neuroscience/proinsulin
C-Peptide (Insulin, Proinsulin) and Interpretations - Labpedia.net. (2020, January 25). Labpedia. https://labpedia.net/c-peptide-insulin-proinsulin-and-interpretations/
C-Peptide Test: MedlinePlus Medical Test. (n.d.). Medlineplus.gov. Retrieved August 18, 2023, from https://medlineplus.gov/lab-tests/c-peptide-test/#:~:text=This%20test%20measures%20the%20level
CDC. (2019). FastStats - Diabetes. Centers for Disease Control and Prevention. https://www.cdc.gov/nchs/fastats/diabetes.htm
CDC. (2021, January 20). Low Blood Sugar (Hypoglycemia). Centers for Disease Control and Prevention. https://www.cdc.gov/diabetes/basics/low-blood-sugar.html
Chan, K. H., Lim, J., Jee, J. E., Aw, J. H., & Lee, S. S. (2020). Peptide–Peptide Co-Assembly: A Design Strategy for Functional Detection of C-peptide, A Biomarker of Diabetic Neuropathy. International Journal of Molecular Sciences, 21(24), 9671. https://doi.org/10.3390/ijms21249671
Clancy, S. (2008). Translation: DNA to mRNA to Protein | Learn Science at Scitable. Www.nature.com. https://www.nature.com/scitable/topicpage/translation-dna-to-mrna-to-protein-393/#:~:text=During%20transcription%2C%20the%20enzyme%20RNA
Geert Jan Biessels. (2008). Diabetic Encephalopathy. 187–205. https://doi.org/10.1007/978-1-59745-311-0_11
Kaleta, E. (2016, January 1). Solving the Mystery of Unexplained Hypoglycemia | AACC.org. Www.aacc.org. https://www.aacc.org/cln/articles/2016/january/solving-the-mystery-of-unexplained-hypoglycemia
Khambatta, C., & Barbaro, R. (2019, August 5). The C-Peptide Test – The Most Important Blood Test for Diabetes. Mastering Diabetes. https://www.masteringdiabetes.org/c-peptide-diabetes-test/
Ko, G. T. C., So, W.-Y., Tong, P. C., Chan, W.-B., Yang, X., Ma, R. C., Kong, A. P., Ozaki, R., Yeung, C.-Y., Chow, C.-C., & Chan, J. C. (2009). Effect of interactions between C peptide levels and insulin treatment on clinical outcomes among patients with type 2 diabetes mellitus. CMAJ : Canadian Medical Association Journal, 180(9), 919–926. https://doi.org/10.1503/cmaj.081545
Luppi, P., & Drain, P. K. (2017). C-peptide antioxidant adaptive pathways in β cells and diabetes. Journal of Internal Medicine, 281(1), 7–24. https://doi.org/10.1111/joim.12522
Mayo Clinic. (2023, January 20). Diabetes - symptoms and causes. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/diabetes/symptoms-causes/syc-20371444
Novac, C., Radulian, G., Orzan, A., & Balgradean, M. (2019). Short Update on C-Peptide and its Clinical Value. Maedica, 14(1), 53–58. https://doi.org/10.26574/maedica.2019.14.1.53
Osborn, C., & Biggers, A. (2020, October 28). What Are the Differences Between Type 1 and Type 2 Diabetes? Healthline. https://www.healthline.com/health/difference-between-type-1-and-type-2-diabetes#prevention
Poteryaeva, O. N., & Usynin, I. F. (2020). Molecular mechanisms of action and physiological effects of the proinsulin C-peptide (a systematic review). Biomeditsinskaya Khimiya, 66(3), 196–207. https://doi.org/10.18097/pbmc20206603196
Robertson, P. (2022, July 25). UpToDate. Www.uptodate.com. https://www.uptodate.com/contents/pancreatic-beta-cell-function/print
Ryk, A., Łosiewicz, A., Michalak, A., & Fendler, W. (2020). Biological Activity of c-Peptide in Microvascular Complications of Type 1 Diabetes—Time for Translational Studies or Back to the Basics? International Journal of Molecular Sciences, 21(24), 9723. https://doi.org/10.3390/ijms21249723
Sima, A. A. F., Kamiya, H., & Guo Li, Z. (2004). Insulin, C-peptide, hyperglycemia, and central nervous system complications in diabetes. European Journal of Pharmacology, 490(1-3), 187–197. https://doi.org/10.1016/j.ejphar.2004.02.056
Sima, A. A. F., & Li, Z. . (2005). The Effect of C-Peptide on Cognitive Dysfunction and Hippocampal Apoptosis in Type 1 Diabetic Rats. Diabetes, 54(5), 1497–1505. https://doi.org/10.2337/diabetes.54.5.1497
Sima, A. A. F., Zhang, W., Kreipke, C. W., Rafols, J. A., & Hoffman, W. H. (2009). Inflammation in Diabetic Encephalopathy is Prevented by C-Peptide. The Review of Diabetic Studies : RDS, 6(1), 37–42. https://doi.org/10.1900/RDS.2009.6.37
Sima, A. A. F., Zhang, W., Li, Z., & Kamiya, H. (2008). The Effects of C-peptide on Type 1 Diabetic Polyneuropathies and Encephalopathy in the BB/Wor-rat. Experimental Diabetes Research, 2008, 230458. https://doi.org/10.1155/2008/230458
Sima, A., & Kamiya, H. (2008). Is C-Peptide Replacement the Missing Link for Successful Treatment of Neurological Complications in Type 1 Diabetes? Current Drug Targets, 9(1), 37–46. https://doi.org/10.2174/138945008783431745
Sima, & Zhang, W. (2011). C-Peptide and Type 1 Diabetic Encephalopathy. 93–109. https://doi.org/10.1007/978-1-61779-391-2_9
Sima, Zhang, W., Muzik, O., Kreipke, C. W., Rafols, J. A., & Hoffman, W. (2009). Sequential Abnormalities in Type 1 Diabetic Encephalopathy and the Effects of C-Peptide. 6(3), 211–222. https://doi.org/10.1900/rds.2009.6.211
Van Huizen, E., & McInerney, G. M. (2020). Activation of the PI3K-AKT Pathway by Old World Alphaviruses. Cells, 9(4), 970. https://doi.org/10.3390/cells9040970
Venugopal, S. K., Mowery, M. L., & Jialal, I. (2020). C Peptide. PubMed; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK526026/
Venugopal, S. K., Mowery, M. L., & Jialal, I. (2023). Biochemistry, C Peptide. PubMed; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK526026/#:~:text=C%2Dpeptide%20is%20secreted%20in
Wahren, J., Ekberg, K., Johansson, J., Henriksson, M., Pramanik, A., Johansson, B.-L., Rigler, R., & Jörnvall, H. (2000). Role of C-peptide in human physiology. American Journal of Physiology-Endocrinology and Metabolism, 278(5), E759–E768. https://doi.org/10.1152/ajpendo.2000.278.5.e759
WHO. (2023). Diabetes. World Health Organization; World Health Organization. https://www.who.int/health-topics/diabetes#tab=tab_1
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