Nature’s Defense: Studying the Antibiotics Properties of the Goldenrod Plant
DOI:
https://doi.org/10.47611/jsrhs.v12i3.4861Keywords:
antibiotics, goldenrod, antibiotic winter, antimicrobial plantsAbstract
Plants have long been known to possess antimicrobial properties and treat various conditions, including cancer (Gonelimali et al., 2018). Recent research has accelerated the use of plant-derived drugs and supplements, pivotal in reducing the strain on fungal-based antibiotics (Veeresham, 2012). However, there have been very few studies to evaluate the individual parts of the plants and their contribution to the antimicrobial properties. This study will be crucial in creating the most potent treatment and using plants more conservatively, potentially leading to the production of different types of antibiotics. This paper focuses on evaluating the antimicrobial properties of the various parts of the Goldenrod plant and the inhibitory mechanisms they use. Tests conducted on the Goldenrod plant against gram-positive and gram-negative bacteria indicate that the roots had the highest antimicrobial effect for the gram-positive bacteria, while the leaves had the highest antimicrobial effect for the gram-negative bacteria. The findings show that specific parts of the plant are specialized in specific types of antimicrobial compounds. When the antibiotics found in different parts of the plant were compared with commercial antibiotics, it was found that the antibiotics present in leaves worked similarly to Streptomycin, while the roots worked differently than any antibiotic that was available to us at the time of the study. While mass spectrometry of the plant compounds is underway, the findings of this study will be extended to other medicinal plants and will help prevent antibiotic winter and the discovery of new antibiotics.
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Clardy, J., Fischbach, M. A., & Currie, C. R. (2009). The natural history of antibiotics. Current Biology, 19(11), R437–R441. https://doi.org/10.1016/j.cub.2009.04.001
Cowan, M. M. (1999). Plant products as antimicrobial agents. Clinical Microbiology Reviews, 12(4), 564–582. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC88925/
D, S., & W, H. (1996, June 1). Tetracyclines: antibiotic action, uptake, and resistance mechanisms. Retrieved from Archives of microbiology website: https://pubmed.ncbi.nlm.nih.gov/8661929/#:~:text=Tetracyclines%20probably%20penetrate%20bacterial%20cells
Elshafie, H. S., Gruľová, D., Baranová, B., Caputo, L., De Martino, L., Sedlák, V., … De Feo, V. (2019). Antimicrobial Activity and Chemical Composition of Essential Oil Extracted from Solidago canadensis L. Growing Wild in Slovakia. Molecules, 24(7), 1206. https://doi.org/10.3390/molecules24071206
GOLDEN ROD. (n.d.). Retrieved from https://academics.hamilton.edu/foodforthought/our_research_files/goldenrod.pdf
Gonelimali, F. D., Lin, J., Miao, W., Xuan, J., Charles, F., Chen, M., & Hatab, S. R. (2018). Antimicrobial Properties and Mechanism of Action of Some Plant Extracts Against Food Pathogens and Spoilage Microorganisms. Frontiers in Microbiology, 9. https://doi.org/10.3389/fmicb.2018.01639
How Do Antibiotics Work? - Nordic Biosite. (2021, March). Retrieved from nordicbiosite.com website: https://nordicbiosite.com/news/how-do-antibiotics-work
Humayun, M. Z., & Ayyappan, V. (2013). Potential roles for DNA replication and repair functions in cell killing by streptomycin. Mutation Research, 749(0), 87–91. https://doi.org/10.1016/j.mrfmmm.2013.07.009
Kırmusaoğlu, S., Gareayaghi, N., & Kocazeybek, B. S. (2019). Introductory Chapter: The Action Mechanisms of Antibiotics and Antibiotic Resistance. In www.intechopen.com. IntechOpen. Retrieved from https://www.intechopen.com/chapters/65914
Liu, J., Cui, X., Liu, Z., Guo, Z., Yu, Z., Yao, Q., … Wang, G. (2019). The Diversity and Geographic Distribution of Cultivable Bacillus-Like Bacteria Across Black Soils of Northeast China. Frontiers in Microbiology, 10(10). https://doi.org/10.3389/fmicb.2019.01424
Llor, C., & Bjerrum, L. (2014). Antimicrobial resistance: Risk associated with antibiotic overuse and initiatives to reduce the problem. Therapeutic Advances in Drug Safety, 5(6), 229–241. https://doi.org/10.1177/2042098614554919
Mayo Clinic. (2022, March 11). Antibiotics: Are you misusing them? Retrieved from Mayo Clinic website: https://www.mayoclinic.org/healthy-lifestyle/consumer-health/in-depth/antibiotics/art-20045720
Ruiz-Gil, T., Acuña, J. J., Fujiyoshi, S., Tanaka, D., Noda, J., Maruyama, F., & Jorquera, M. A. (2020). Airborne bacterial communities of outdoor environments and their associated influencing factors. Environment International, 145(145), 106156. https://doi.org/10.1016/j.envint.2020.106156
Sullivan, G. J., Delgado, N. N., Maharjan, R., & Cain, A. K. (2020). How antibiotics work together: molecular mechanisms behind combination therapy. Current Opinion in Microbiology, 57, 31–40. https://doi.org/10.1016/j.mib.2020.05.012
Tryptic Soy Agar TSA | Principle | Preparation | Interpretation. (n.d.). Retrieved from microbiologie-clinique.com website: https://microbiologie-clinique.com/trypticase-soy-agar-principle-interpretation.html
Veeresham, C. (2012). Natural products derived from plants as a source of drugs. Journal of Advanced Pharmaceutical Technology & Research, 3(4), 200. https://doi.org/10.4103/2231-4040.104709
Wang, F., Zhou, H., Olademehin, O. P., Kim, S. J., & Tao, P. (2018). Insights into Key Interactions between Vancomycin and Bacterial Cell Wall Structures. ACS Omega, 3(1), 37–45. https://doi.org/10.1021/acsomega.7b01483
Yip, D. W., & Gerriets, V. (2022, May 19). Penicillin. Retrieved from PubMed website: https://www.ncbi.nlm.nih.gov/books/NBK554560/
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