Reactions to SARS-CoV-2: The Effectiveness of the Body’s Immunological Memory
DOI:
https://doi.org/10.47611/jsrhs.v12i1.4359Keywords:
COVID-19, Immune Memory, SARS-CoV-2Abstract
Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, is a worldwide pandemic which resulted in significant morbidity and mortality. After being exposed to SARS-CoV-2 infection, some patients (especially elderly patients) begin to develop severe COVID-19. Infected individuals begin to produce hyper-inflammatory responses in the body. These responses build immunological memory, which helps to determine one's protection against reinfection, disease risk, and vaccine efficacy. This research paper aims to answer the question of whether immunological memory against COVID-19 is retained in individuals after contraction of the virus. Through a compilation of multiple research studies, a clear correlation was made between coronavirus pathogens and antibody/memory cell responses. The original hypothesis, which focused on the efficacy of immune memory against COVID-19, was partially supported by the results. While it was found that immunological memory after the virus is present, there are limitations to the testing group. This research’s purpose is to help readers understand the body's immune response system and its role in controlling COVID-19 infection. With this information, other researchers can further study and develop treatments for future deadly infections/diseases similar to COVID-19.
Downloads
References or Bibliography
Dan, J. M et al. (2021, January 6). Immunological memory to SARS-COV-2 assessed for up to 8 ... - science. Retrieved December 1, 2022, from https://www.science.org/doi/10.1126/science.abf4063
Centers for Disease Control and Prevention. (2022, December 19). Coronavirus disease 2019 (covid-19). Centers for Disease Control and Prevention. Retrieved January 6, 2023, from https://www.cdc.gov/dotw/covid-19/index.html
Ciabattini, A., Pastore, G., Fiorino, F., Polvere, J., Lucchesi, S., Pettini, E., Auddino, S., Rancan, I., Durante, M., Miscia, M., Rossetti, B., Fabbiani, M., Montagnani, F., & Medaglini, D. (2021, August 27). Evidence of SARS-COV-2-specific memory B cells six months after vaccination with the BNT162B2 mrna vaccine. Frontiers. Retrieved January 6, 2023, from https://www.frontiersin.org/articles/10.3389/fimmu.2021.740708/full
Immunological memory - immunobiology - NCBI bookshelf. (n.d.). Retrieved January 7, 2023, from https://www.ncbi.nlm.nih.gov/books/NBK27158/
Janeway, C. A. Jr., Travers, P., Walport, M., & Shlomchik, M. J. (2001). Immunobiology: The Immune System in Health and Disease (5th ed.). New York: Garland Science. Available from: https://www.ncbi.nlm.nih.gov/books/NBK10757/
Janeway's Immunobiology. (2017). Murphy, K., & Weaver, C. (Eds.). Garland Science. Chapter 3, Antibodies and Antigens.
Jung, J. H., Rha, M.-S., Sa, M., Choi, H. K., Jeon, J. H., Seok, H., Park, D. W., Park, S.-H., Jeong, H. W., Choi, W. S., & Shin, E.-C. (2021, June 30). SARS-COV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells. Nature News. Retrieved January 6, 2023, from https://www.nature.com/articles/s41467-021-24377-1
National Human Genome Research Institute. (n.d.). Lymphocyte. Genetics Home Reference. Retrieved February 26, 2023, from https://ghr.nlm.nih.gov/primer/cells/lymphocyte
Netea, M. G., & Li, Y. (2021, June 9). Immune memory in individuals with COVID-19. Nature News. Retrieved January 6, 2023, from https://www.nature.com/articles/s41556-021-00689-8
Quast, I., & Tarlinton, D. (2021, February 9). B cell memory: Understanding covid-19. Immunity. Retrieved January 6, 2023, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826135/
Rodda, L. B., Netland, J., Shehata, L., Pruner, K. B., Morawski, P. A., Thouvenel, C., Takehara, K. K., Eggenberger, J., Hemann, E., Waterman, H. R., Fahning, M. L., Chen, Y., Rathe, J., Stokes, C., Wrenn, S., Fiala, B., Carter, L., Hamerman, J. A., King, N. P., … Pepper, M. (2020, August 13). Functional sars-COV-2-specific immune memory persists after mild COVID-19. Research square. Retrieved January 6, 2023, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430600/
Sansom, W. (2021, December 23). Immune memory less durable after severe COVID-19, study suggests. UT Health San Antonio. Retrieved January 6, 2023, from https://news.uthscsa.edu/immune-memory-less-durable-after-severe-covid-19-study-suggests/
Scudellari, M. (2021, July 28). How the coronavirus infects cells - and why delta is so dangerous. Nature News. Retrieved January 6, 2023, from https://www.nature.com/articles/d41586-021-02039-y
World Health Organization. (n.d.). Who coronavirus (COVID-19) dashboard. World Health Organization. Retrieved January 6, 2023, from https://covid19.who.int/
King, J., Kosinski-Collins, M., & Sundberg, E. (n.d.). Coronavirus Structure, Vaccine and Therapy Development. Biophysical Society. https://www.biophysics.org/blog/coronavirus-structure-vaccine-and-therapy-development
Published
How to Cite
Issue
Section
Copyright (c) 2023 Abhaya Saridena, Ananya Saridena; Jothsna Kethar
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Copyright holder(s) granted JSR a perpetual, non-exclusive license to distriute & display this article.