The Assessment of Dietary interventions on Stem Cell Fate, Homeostatic Mechanisms, and Disease
DOI:
https://doi.org/10.47611/jsrhs.v12i2.4288Keywords:
stem cells, stem cell fate, prolonged fasting, caloric restriction, ketogenic diet, high fat diet, dietary interventions, organismal metabolism, metabolism, ketone bodies, ketosis, insulin resistance, disease, homeostasisAbstract
Economic growth and globalisation have increased food availability and disposable income, causing people to rely on nutrient-poor fast foods due to their low price and wide availability instead of nutritious produce. Global statistics show the population consumes exponentially more fats and carbohydrates than proteins, vegetables, and fruits. This dietary pattern negatively impacts public health, increasing prevalence of obesity and diet related diseases like diabetes, heart disease, and hypertension. When used appropriately, dietary interventions have a profound effect on stem cell regeneration and homeostasis, hormone signaling, and prevalence of disease and obesity, posing strong potential in regenerative medicine and non-communicable disease treatment. This review studies caloric restriction, prolonged fasting, the ketogenic diet, and the high fat diet and outlines their effect on stem cell fate and numbers, hormone and metabolism levels, and prevalence of disease and discusses the advantages, disadvantages, and future directions of each dietary intervention.
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