The Various Methods to Prevent Lithium Toxicity in Treatment for Patients with Bipolar Disorder
DOI:
https://doi.org/10.47611/jsrhs.v12i1.4099Keywords:
Bipolar disorder, lithium treatment, renal damage, lithium toxicity, dosing regimen, alternate BD treatment, optical spectroscopy, therapeutic rangeAbstract
Bipolar disorder (BD) is a serious mental illness that leads to considerable shifts in mood, energy, and physical activity levels, impairing a person’s ability to complete day-to-day tasks. About 4.4% of adults in the US report having experienced an episode of BD at least once in their life, and approximately 82.9% of people with BD are left severely impaired. To combat this, doctors prescribe lithium, which is an effective mood stabilizer that can regulate the extreme highs and lows of BD. However, lithium is a toxic substance when it exceeds the therapeutic range, requiring frequent trips to the hospital to evaluate blood lithium levels Such monitoring may not always be effectively feasible, especially for patients experiencing a mental health crisis or patients in rural areas without local medical facilities.
Research studies have been conducted to provide patients with alternative methods to avoid lithium toxicity including ways to check the lithium levels on their own Additionally, studies investigate the ideal dosing regimen to prevent toxic side effects, while others aim to prevent toxicity before it happens.
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Adida, M. , Jollant, F. , Clark, L. , Guillaume, S. , Goodwin, G. M. , Azorin, J. -M. , & Courtet, P. (2015). Lithium might be associated with better decision-making performance in euthymic bipolar patients. European Neuropsychopharmacology, 25(6), 788–797. https://doi. org/10. 1016/j. euroneuro. 2015. 03. 003
Alsady, M. , Baumgarten, R. , Deen, P. M. T. , & de Groot, T. (2016). Lithium in the Kidney: Friend and Foe? Journal of the American Society of Nephrology : JASN, 27(6), 1587–1595. https://doi. org/10. 1681/ASN. 2015080907
Berg, J. M. , Tymoczko, J. L. , & Stryer, L. (2002). Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th Edition. https://www. ncbi. nlm. nih. gov/books/NBK21205/
Bipolar disorder | NAMI: National Alliance on Mental Illness. (n. d. ). Retrieved November 7, 2021, from https://www. nami. org/About-Mental-Illness/Mental-Health-Conditions/Bipolar-Disorder/Treatment
Bipolar disorder—Symptoms and causes. (n. d. ). Mayo Clinic. Retrieved October 20, 2021, from https://www. mayoclinic. org/diseases-conditions/bipolar-disorder/symptoms-causes/syc-20355955
Boston, 677 Huntington Avenue, & Ma 02115 +1495-1000. (2016, February 11). Global burden of mental illness underestimated. News. https://www.hsph.harvard.edu/news/hsph-in-the-news/global-burden-of-mental-illness-underestimated/
Carter, L. , Zolezzi, M. , & Lewczyk, A. (2013). An Updated Review of the Optimal Lithium Dosage Regimen for Renal Protection. The Canadian Journal of Psychiatry, 58(10), 595–600. https://doi. org/10. 1177/070674371305801009
Flame Photometry (Theory): Inorganic Chemistry Virtual Lab: Chemical Sciences: Amrita Vishwa Vidyapeetham Virtual Lab. (n. d. ). Retrieved October 24, 2021, from https://vlab. amrita. edu/?sub=2&brch=193&sim=1351&cnt=1
Gitlin, M. (2016). Lithium side effects and toxicity: Prevalence and management strategies. International Journal of Bipolar Disorders, 4(1), 27. https://doi. org/10. 1186/s40345-016-0068-y
Machado-Vieira, R. , Manji, H. K. , & Zarate, C. A. (2009). The role of lithium in the treatment of bipolar disorder: Convergent evidence for neurotrophic effects as a unifying hypothesis. Bipolar Disorders, 11(Suppl 2), 92–109. https://doi. org/10. 1111/j. 1399-5618. 2009. 00714. x
McKnight, R. F. , Adida, M. , Budge, K. , Stockton, S. , Goodwin, G. M. , & Geddes, J. R. (2012). Lithium toxicity profile: A systematic review and meta-analysis. The Lancet, 379(9817), 721–728. https://doi. org/10. 1016/S0140-6736(11)61516-X
NIMH » Bipolar Disorder. (n. d. ). Retrieved November 7, 2021, from https://www. nimh. nih. gov/health/statistics/bipolar-disorder
Novell, M. , Guinovart, T. , Blondeau, P. , Xavier Rius, F. , & J. Andrade, F. (2014). A paper-based potentiometric cell for decentralized monitoring of Li levels in whole blood. Lab on a Chip, 14(7), 1308–1314. https://doi. org/10. 1039/C3LC51098K
Ott, C. A. (2018). Treatment of anxiety disorders in patients with comorbid bipolar disorder. The Mental Health Clinician, 8(6), 256–263. https://doi.org/10.9740/mhc.2018.11.256
Post, R. M., Frye, M. A., Denicoff, K. D., Leverich, G. S., Kimbrell, T. A., & Dunn, R. T. (1998). Beyond Lithium in the Treatment of Bipolar Illness. Neuropsychopharmacology, 19(3), Article 3. https://doi.org/10.1016/S0893-133X(98)00020-7
Qassem, M. , Constantinou, L. , Triantis, IasonasI. F. , Hickey, M. , Palazidou, E. , & Kyriacou, P. A. (2019). A Method for Rapid, Reliable, and Low-Volume Measurement of Lithium in Blood for Use in Bipolar Disorder Treatment Management. IEEE Transactions on Biomedical Engineering, 66(1), 130–137. https://doi. org/10. 1109/TBME. 2018. 2836148
Qassem, M. , Hickey, M. , & Kyriacou, P. A. (2016). Colorimetric determinations of lithium levels in drop-volumes of human plasma for monitoring patients with bipolar mood disorder. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2016, 5160–5163. https://doi. org/10. 1109/EMBC. 2016. 7591889
Sani, G., Perugi, G., & Tondo, L. (2017). Treatment of Bipolar Disorder in a Lifetime Perspective: Is Lithium Still the Best Choice? Clinical Drug Investigation, 37(8), 713–727. https://doi.org/10.1007/s40261-017-0531-2
Shah, N. , Grover, S. , & Rao, G. P. (2017). Clinical Practice Guidelines for Management of Bipolar Disorder. Indian Journal of Psychiatry, 59(Suppl 1), S51–S66. https://doi. org/10. 4103/0019-5545. 196974
Won, E., & Kim, Y.-K. (2017). An Oldie but Goodie: Lithium in the Treatment of Bipolar Disorder through Neuroprotective and Neurotrophic Mechanisms. International Journal of Molecular Sciences, 18(12), 2679. https://doi.org/10.3390/ijms18122679
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