A Review on the Natural Treatments of Allergic Rhinitis
DOI:
https://doi.org/10.47611/jsrhs.v12i1.3984Keywords:
Herbal Treatments, Allergic Rhinitis, Butterbur, Astragalus Membranaceus, Tinospora Cordifolia, Petasin, Astragalus Polysaccharide, Diterpenoid Lactones, Anaphylaxis, Histamine, Cytokines, Eosinophil, Immunoglobulin E, Leukotriene, Natural Treatments, Rhinorrhea, AntihistaminesAbstract
Allergic rhinitis affects millions of people and can significantly lower an individual’s quality of life. The most common treatment for allergic rhinitis lies in over-the-counter medications. However, most over-the-counter antihistamines are either sedating, interfere with an individual’s life, and make them more prone to accidents or are non-sedating, but less researched. An increasing distrust of pharmaceuticals alongside the development of tolerance and even eventual withdrawal to treatment has made it necessary to evaluate other avenues of allergy treatment, including herbal medications.
An analysis of 9 clinical trials on three herbs, butterbur, astragalus membranaceus, and tinospora cordifolia, determined that the butterbur’s efficacy is the most well-established. Meanwhile, astragalus membranaceus features the most potential for success in treating allergies, but confidence within its clinical trials is also the lowest. These herbs are generally more cost effective and incur fewer side effects than current antihistamines, but more research is necessary to ensure the safety of their consumption.
Downloads
References or Bibliography
Small, P., Keith, P.K. & Kim, H. Allergic rhinitis. Allergy Asthma Clin Immunol 14, 51 (2018). https://doi.org/10.1186/s13223-018-0280-7.
Min Y. G. (2010). The pathophysiology, diagnosis and treatment of allergic rhinitis. Allergy, asthma & immunology research, 2(2), 65–76. https://doi.org/10.4168/aair.2010.2.2.65.
Akhouri S, House SA. Allergic Rhinitis. [Updated 2022 Jun 5]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538186/.
Small, P., Keith, P. K., & Kim, H. (2018). Allergic rhinitis. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 14(Suppl 2), 51. https://doi.org/10.1186/s13223-018-0280-7.
Randall, K. L., & Hawkins, C. A. (2018). Antihistamines and allergy. Australian prescriber, 41(2), 41–45. https://doi.org/10.18773/austprescr.2018.013.
So, M., Bozzo, P., Inoue, M., & Einarson, A. (2010). Safety of antihistamines during pregnancy and lactation. Canadian family physician Medecin de famille canadien, 56(5), 427–429.
Chung, A. H., La Grenade, L., & Harinstein, L. M. (2019). Pruritus after discontinuation of cetirizine. Therapeutic advances in drug safety, 10, 2042098619859996. https://doi.org/10.1177/2042098619859996.
U.S. Department of Health and Human Services. (n.d.). Butterbur. National Center for Complementary and Integrative Health. Retrieved August 10, 2022, from https://www.nccih.nih.gov/health/butterbur.
Thomet OA, Simon HU. Petasins in the treatment of allergic diseases: results of preclinical and clinical studies. Int Arch Allergy Immunol. 2002 Oct;129(2):108-12. doi: 10.1159/000065884. PMID: 12403927.
Schapowal A, Petasites Study Group. Butterbur Ze339 for the Treatment of Intermittent Allergic Rhinitis: Dose-Dependent Efficacy in a Prospective, Randomized, Double-blind, Placebo-Controlled Study. Arch Otolaryngol Head Neck Surg. 2004;130(12):1381–1386. doi:10.1001/archotol.130.12.1381.
Shimoda H, Tanaka J, Yamada E, Morikawa T, Kasajima N, Yoshikawa M. Anti type I allergic property of Japanese butterbur extract and its mast cell degranulation inhibitory ingredients. J Agric Food Chem. 2006 Apr 19;54(8):2915-20. doi: 10.1021/jf052994o. PMID: 16608208.
Fukuishi N, Murakami S, Ohno A, Yamanaka N, Matsui N, Fukutsuji K, Yamada S, Itoh K, Akagi M. Does β-hexosaminidase function only as a degranulation indicator in mast cells? The primary role of β-hexosaminidase in mast cell granules. J Immunol. 2014 Aug 15;193(4):1886-94. doi: 10.4049/jimmunol.1302520. Epub 2014 Jul 11. PMID: 25015817.
Duroudier NP, Tulah AS, Sayers I. Leukotriene pathway genetics and pharmacogenetics in allergy. Allergy. 2009 Jun;64(6):823-39. doi: 10.1111/j.1398-9995.2009.02015.x. Epub 2009 Mar 26. PMID: 19416143.
Idriss HT, Naismith JH. TNF alpha and the TNF receptor superfamily: structure-function relationship(s). Microsc Res Tech. 2000 Aug 1;50(3):184-95. doi: 10.1002/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H. PMID: 10891884.
Shih, C. H., Huang, T. J., Chen, C. M., Lin, Y. L., & Ko, W. C. (2011). S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness. Evidence-based complementary and alternative medicine : eCAM, 2011, 132374. https://doi.org/10.1093/ecam/nep088.
U.S. Department of Health and Human Services. (n.d.). Astragalus. National Center for Complementary and Integrative Health. Retrieved August 10, 2022, from https://www.nccih.nih.gov/health/astragalus#:~:text=Its%20root%20is%20used%20for,chronic%20kidney%20disease%2C%20among%20others.
Zheng Y, Ren W, Zhang L, Zhang Y, Liu D and Liu Y (2020) A Review of the Pharmacological Action of Astragalus Polysaccharide. Front. Pharmacol. 11:349. doi: 10.3389/fphar.2020.00349.
Du L, Ye X, Li M, Wang H, Zhang B, Zheng R, Wang Y, Mechanisms of traditional Chinese medicines in the treatment of allergic rhinitis using a network biology approach, Journal of Traditional Chinese Medical Sciences (2017), doi: 10.1016/j.jtcms.2016.11.007.
Matkovic Z, Zivkovic V, Korica M, Plavec D, Pecanic S, Tudoric N. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res. 2010 Feb;24(2):175-81. doi: 10.1002/ptr.2877. PMID: 19504468.
Makino T, Ito Y, Sasaki SY, Fujimura Y, Kano Y. Preventive and curative effects of Gyokuheifu-san, a formula of traditional Chinese medicine, on allergic rhinitis induced with Japanese cedar pollens in guinea pig. Biol Pharm Bull. 2004 Apr;27(4):554-8. doi: 10.1248/bpb.27.554. PMID: 15056865.
Deo, S. S., Mistry, K. J., Kakade, A. M., & Niphadkar, P. V. (2010). Role played by Th2 type cytokines in IgE mediated allergy and asthma. Lung India : official organ of Indian Chest Society, 27(2), 66–71. https://doi.org/10.4103/0970-2113.63609.
Teixeira LK, Fonseca BP, Barboza BA, Viola JP. The role of interferon-gamma on immune and allergic responses. Mem Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:137-44. doi: 10.1590/s0074-02762005000900024. Epub 2005 Jun 14. PMID: 15962113.
Vlaykov, A. N., Tacheva, T. T., Vlaykova, T. I., & Stoyanov, V. K. (2020). Serum and local IL-4, IL-5, IL-13 and immunoglobulin E in allergic rhinitis. Postepy dermatologii i alergologii, 37(5), 719–724. https://doi.org/10.5114/ada.2020.100483.
He X, Liu L, Luo X, Zhu J, Yang H, Wang J, Chen L, Zhong L. Astragalus Polysaccharide Relieves Inflammatory Responses in Guinea Pigs with Allergic Rhinitis via Ameliorating NF-kB-Mediated Treg/Th17 Imbalance. Am J Rhinol Allergy. 2022 Sep;36(5):638-648. doi: 10.1177/19458924221098847. Epub 2022 May 18. PMID: 35585694.
Saha, S., & Ghosh, S. (2012). Tinospora cordifolia: One plant, many roles. Ancient science of life, 31(4), 151–159. https://doi.org/10.4103/0257-7941.107344.
Gan, L., Zheng, Y., Deng, L., Sun, P., Ye, J., Wei, X., Liu, F., Yu, L., Ye, W., Fan, C., Liu, J., & Zhang, W. (2019). Diterpenoid Lactones with Anti-Inflammatory Effects from the Aerial Parts of Andrographis paniculata. Molecules (Basel, Switzerland), 24(15), 2726. https://doi.org/10.3390/molecules24152726.
Badar VA, Thawani VR, Wakode PT, Shrivastava MP, Gharpure KJ, Hingorani LL, Khiyani RM. Efficacy of Tinospora cordifolia in allergic rhinitis. J Ethnopharmacol. 2005 Jan 15;96(3):445-9. doi: 10.1016/j.jep.2004.09.034. Epub 2004 Nov 23. PMID: 15619563.
Geeta, S., Kamath, M. S., Nagendra, K., & Shenoy, R. P. (2017). A clinical analysis of evaluating the usefulness and efficacy of the ayurvedic drug tinospora cordifolia in humans. Advanced Science Letters, 23(3), 2007–2008. https://doi.org/10.1166/asl.2017.8551.
Dao DPD, Le PH. Histology, Goblet Cells. [Updated 2022 May 5]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553208/.
Hosoki, K., Itazawa, T., Boldogh, I., & Sur, S. (2016). Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation. Current opinion in allergy and clinical immunology, 16(1), 45–50. https://doi.org/10.1097/ACI.0000000000000231.
Published
How to Cite
Issue
Section
Copyright (c) 2023 Sissi Zhang; Angela Cannata
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Copyright holder(s) granted JSR a perpetual, non-exclusive license to distriute & display this article.