Investigating the Role of Prescription Drugs on the Gut Microbiome
DOI:
https://doi.org/10.47611/jsrhs.v11i4.3841Keywords:
microbiology, opioids, antidepressants, marijuana, antimicrobialAbstract
The effect of prescription drugs on gut microbiome is a relevant and under-researched issue in the modern medicine-dependent world. The gut plays an important role in body function, and dysbiosis can influence the development of conditions such as obesity, diabetes, irritable bowel syndrome, inflammatory bowel disease, allergic reactions and many other human diseases. In this study we systematically organize and compare different commonly used prescription drugs. Studies based on murine and human subjects were analyzed on each of the three following classes: opioids, antidepressants, and marijuana to understand the role that these play on the microbiome. Opioids and antidepressants were shown to significantly change and modulate the microbial composition found in the gut that is associated with disease. Marijuana demonstrated the most conflicting results out of all three classes and needs further investigation. This information is significant for patients that are currently using these drugs as well as physicians to understand the role that these drugs play inadvertently, and to inform physicians to be more cautious when prescribing these drugs.
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