Design a Workflow for the Application of Machine Learning in Diagnosis of Cancer Metastasis

Authors

  • Baichuan Peng Chengdu Hongwen School

DOI:

https://doi.org/10.47611/jsrhs.v11i3.3774

Keywords:

Artificial Intelligence (AI), Machine learning, Cancer malignancy, Cancer diagnosis

Abstract

Benign tumors can turn into malignant tumors if they are metastatic. Pathological analysis of cancer tissue is the major method for the diagnosis of cancer malignancy and has been widely used for decades. The analysis is based on the specific features of the malignant tissues with metastatic cancer cells. Nevertheless, the diagnosis fully relies on experts’ efforts, which is a time-consuming process. Also, the decision based on experts’ experiences could be empirical. In this mini review work, we introduced the definition and the diagnosis of cancer malignancy and pointed out the disadvantages of the traditional diagnosis. To improve the efficiency and accuracy of the diagnosis, we proposed a novel workflow for the diagnosis of cancer malignancy. In this workflow, we integrated the in vitro primary cancer cell culture and the machine learning algorithms. After training with big data that consists of images with known features of malignancy status, the machine learning algorithms can recognize the cancer malignancy to perform the diagnosis for cancer patients.

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References or Bibliography

Matz, M., et al., The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2). Gynecol Oncol, 2017. 144(2): p. 405-413.

Brierley, J., M. Gospodarowicz, and B. O'Sullivan, The principles of cancer staging. Ecancermedicalscience, 2016. 10: p. ed61.

Kim, H., et al., Rapid histologic diagnosis using quick fluorescence staining and tissue confocal microscopy. Microsc Res Tech, 2019. 82(6): p. 892-897.

Peng, X.-H., et al., Real-time Detection of Gene Expression in Cancer Cells Using Molecular Beacon Imaging: New Strategies for Cancer Research. Cancer Research, 2005. 65(5): p. 1909-1917.

Shackleton, M., Normal stem cells and cancer stem cells: similar and different. Seminars in Cancer Biology, 2010. 20(2): p. 85-92.

Gupta, S., A. Gupta, and Y. Kumar, Artificial intelligence techniques in Cancer research: Opportunities and challenges. 2021. 411-416.

涛, 徐.姜.段.华.孙., Watson for Oncology 在乳腺癌治疗中的应用与思考. 中国研究型医院, 2018. 5(3): p. 19-24.

Siegel, R.L., et al., Cancer Statistics, 2021. CA: A Cancer Journal for Clinicians, 2021. 71(1): p. 7-33.

DeGrave, A.J., J.D. Janizek, and S.I. Lee, AI for radiographic COVID-19 detection selects shortcuts over signal. medRxiv, 2020.

Oren, O., B.J. Gersh, and D.L. Bhatt, Artificial intelligence in medical imaging: switching from radiographic pathological data to clinically meaningful endpoints. Lancet Digit Health, 2020. 2(9): p. e486-e488.

Schneider, A., G. Hommel, and M. Blettner, Linear regression analysis: part 14 of a series on evaluation of scientific publications. Deutsches Arzteblatt international, 2010. 107 44: p. 776-82.

Zhou, Y., Understanding the cancer/tumor biology from 2D to 3D. J Thorac Dis, 2016. 8(11): p. E1484-e1486.

Dlamini, Z., et al., Artificial intelligence (AI) and big data in cancer and precision oncology. Computational and Structural Biotechnology Journal, 2020. 18: p. 2300 - 2311.

Romero-Garcia, S., et al., Tumor cell metabolism: an integral view. Cancer Biol Ther, 2011. 12(11): p. 939-48.

Thakor, J., et al., Engineered hydrogels for brain tumor culture and therapy. Bio-Design and Manufacturing, 2020. 3(3): p. 203-226.

Ding, Z.Z., et al., Simulation of ECM with silk and chitosan nanocomposite materials. Journal of Materials Chemistry B, 2017. 5(24): p. 4789-4796.

Rindi, G., et al., ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: Prognostic evaluation by pathological analysis. Gastroenterology, 1999. 116(3): p. 532-542.

Im, K., et al., An Introduction to Performing Immunofluorescence Staining, in Biobanking: Methods and Protocols, W.H. Yong, Editor. 2019, Springer New York: New York, NY. p. 299-311.

Levi, I., et al., Characterization of tumor infiltrating natural killer cell subset. Oncotarget, 2015. 6(15): p. 13835-43.

Buscema, M., Back Propagation Neural Networks. Substance Use & Misuse, 1998. 33(2): p. 233-270.

Cao, W., et al., A review on neural networks with random weights. Neurocomputing, 2018. 275: p. 278-287.

De Wilde, P., Backpropagation, in Neural Network Models: Theory and Projects, P. De Wilde, Editor. 1997, Springer London: London. p. 33-52.

S, A. and Y. Zhang, A Review on Back-Propagation Neural Networks in the Application of Remote Sensing Image Classification. Journal of Earth Science and Engineering, 2015. 5.

Zhao, J., Visualization of BP neural network using parallel coordinates. 2010.

Bi, W.L., et al., Artificial intelligence in cancer imaging: Clinical challenges and applications. CA Cancer J Clin, 2019. 69(2): p. 127-157.

Benque, D., et al., Bio Model Analyzer: Visual Tool for Modeling and Analysis of Biological Networks. 2012. p. 686-692.

Published

08-31-2022

How to Cite

Peng, B. (2022). Design a Workflow for the Application of Machine Learning in Diagnosis of Cancer Metastasis. Journal of Student Research, 11(3). https://doi.org/10.47611/jsrhs.v11i3.3774

Issue

Section

HS Research Projects