The Explanation of the dependency of the efficacy of ADHD treatments on the age of the recipient.

Authors

  • Rebecca Chew YKPao School

DOI:

https://doi.org/10.47611/jsrhs.v11i3.3465

Keywords:

ADHD, ADHD treatment

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent neuropsychiatric disorder, affecting people of all age groups. Several treatment methods have proven to be effective in ameliorating ADHD symptoms, most falling under the categories of stimulants, non-stimulants and non-pharmacological. However, many experimental studies have shown that the efficacy of certain ADHD treatments is dependent on the age of the subject. In this paper, I will be providing insight into possible explanations of this phenomenon. By understanding this, not only can we better understand the changes that occur in the brain with age, but also the disorder itself and possible treatment methods. 

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References or Bibliography

Cassidy, C. M., Zucca, F. A., Girgis, R. R., Baker, S. C., Weinstein, J. J., Sharp, M. E., Bellei, C., Valmadre, A., Vanegas, N., Kegeles, L. S., Brucato, G., Kang, U. J., Sulzer, D., Zecca, L., Abi-Dargham, A., & Horga, G. (2019). Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain. Proceedings of the National Academy of Sciences, 116(11), 5108–5117. https://doi.org/10.1073/pnas.1807983116

Caye, A., Swanson, J. M., Coghill, D., & Rohde, L. A. (2019). Treatment strategies for ADHD: an evidence-based guide to select optimal treatment. In Molecular Psychiatry (Vol. 24, Issue 3, pp. 390–408). Nature Publishing Group. https://doi.org/10.1038/s41380-018-0116-3

Danielson, M. L., Visser, S. N., Chronis-Tuscano, A., & DuPaul, G. J. (2018). A National Description of Treatment among United States Children and Adolescents with Attention-Deficit/Hyperactivity Disorder. The Journal of Pediatrics, 192, 240-246.e1. https://doi.org/10.1016/j.jpeds.2017.08.040

de Crescenzo, F., Cortese, S., Adamo, N., & Janiri, L. (2017). Pharmacological and non-pharmacological treatment of adults with ADHD: a meta-review. Evidence Based Mental Health, 20(1), 4–11. https://doi.org/10.1136/eb-2016-102415

Faraone, S. v., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005). Molecular Genetics of Attention-Deficit/Hyperactivity Disorder. Biological Psychiatry, 57(11), 1313–1323. https://doi.org/10.1016/j.biopsych.2004.11.024

Hämmerer, D., Callaghan, M. F., Hopkins, A., Kosciessa, J., Betts, M., Cardenas-Blanco, A., Kanowski, M., Weiskopf, N., Dayan, P., Dolan, R. J., & Düzel, E. (2018). Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events. Proceedings of the National Academy of Sciences, 115(9), 2228–2233. https://doi.org/10.1073/pnas.1712268115

Hodgson, K., Hutchinson, A. D., & Denson, L. (2014). Nonpharmacological Treatments for ADHD. Journal of Attention Disorders, 18(4), 275–282. https://doi.org/10.1177/1087054712444732

Kolar, D., Keller, A., Golfinopoulos, M., Cumyn, L., Syer, C., & Hechtman, L. (2008). Treatment of adults with attention-deficit/hyperactivity disorder. Neuropsychiatric Disease and Treatment, 4(2), 389–403. https://doi.org/10.2147/ndt.s6985

KRATOCHVIL, C. J., HEILIGENSTEIN, J. H., DITTMANN, R., SPENCER, T. J., BIEDERMAN, J., WERNICKE, J., NEWCORN, J. H., CASAT, C., MILTON, D., & MICHELSON, D. (2002). Atomoxetine and Methylphenidate Treatment in Children With ADHD: A Prospective, Randomized, Open-Label Trial. Journal of the American Academy of Child & Adolescent Psychiatry, 41(7), 776–784. https://doi.org/10.1097/00004583-200207000-00008

Li, Y., Gao, J., He, S., Zhang, Y., & Wang, Q. (2017). An Evaluation on the Efficacy and Safety of Treatments for Attention Deficit Hyperactivity Disorder in Children and Adolescents: a Comparison of Multiple Treatments. Molecular Neurobiology, 54(9), 6655–6669. https://doi.org/10.1007/s12035-016-0179-6

McEwen, B. S., Nasca, C., & Gray, J. D. (2016). Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex. Neuropsychopharmacology, 41(1), 3–23. https://doi.org/10.1038/npp.2015.171

Michelson, D., Adler, L., Spencer, T., Reimherr, F. W., West, S. A., Allen, A. J., Kelsey, D., Wernicke, J., Dietrich, A., & Milton, D. (2003). Atomoxetine in adults with ADHD: two randomized, placebo-controlled studies. Biological Psychiatry, 53(2), 112–120. https://doi.org/10.1016/S0006-3223(02)01671-2

Peter R., H. (1979). Synaptic density in human frontal cortex — Developmental changes and effects of aging. Brain Research, 163(2), 195–205. https://doi.org/10.1016/0006-8993(79)90349-4

Peters, A., Sethares, C., & Luebke, J. I. (2008). Synapses are lost during aging in the primate prefrontal cortex. Neuroscience, 152(4), 970–981. https://doi.org/10.1016/j.neuroscience.2007.07.014

Rutter, M., Moffitt, T. E., & Caspi, A. (2006). Gene-environment interplay and psychopathology: multiple varieties but real effects. Journal of Child Psychology and Psychiatry, 47(3–4), 226–261. https://doi.org/10.1111/j.1469-7610.2005.01557.x

Segura-Aguilar, J., & Huenchuguala, S. (2018). Aminochrome Induces Irreversible Mitochondrial Dysfunction by Inducing Autophagy Dysfunction in Parkinson’s Disease. Frontiers in Neuroscience, 12, 106. https://doi.org/10.3389/fnins.2018.00106

Simpson, T., Kure, C., & Stough, C. (2019). Assessing the Efficacy and Mechanisms of Pycnogenol® on Cognitive Aging From In Vitro Animal and Human Studies. Frontiers in Pharmacology, 10. https://doi.org/10.3389/fphar.2019.00694

Spencer, T. J., Landgraf, J. M., Adler, L. A., Weisler, R. H., Anderson, C. S., & Youcha, S. H. (2008). Attention-Deficit/Hyperactivity Disorder-Specific Quality of Life With Triple-Bead Mixed Amphetamine Salts (SPD465) in Adults. The Journal of Clinical Psychiatry, 69(11), 1766–1775. https://doi.org/10.4088/JCP.v69n1112

Štuhec, M., Švab, V., & Locatelli, I. (2015). Prevalence and incidence of attention-deficit/hyperactivity disorder in Slovenian children and adolescents: a database study from a national perspective. Croatian Medical Journal, 56(2), 159–165. https://doi.org/10.3325/cmj.2015.56.159

Tenenbaum, S., Paull, J. C., Sparrow, E. P., Dodd, D. K., & Green, L. (2002). An experimental comparison of Pycnogenol® and methylphenidate in adults with Attention-Deficit/ Hyperactivity Disorder (ADHD). Journal of Attention Disorders, 6(2), 49–60. https://doi.org/10.1177/108705470200600201

Thapar, A., Cooper, M., Eyre, O., & Langley, K. (2013). Practitioner Review: What have we learnt about the causes of ADHD? Journal of Child Psychology and Psychiatry, 54(1), 3–16. https://doi.org/10.1111/j.1469-7610.2012.02611.x

Trebatická, J., Kopasová, S., Hradečná, Z., Činovský, K., Škodáček, I., Šuba, J., Muchová, J., Žitňanová, I., Waczulíková, I., Rohdewald, P., & Ďuračková, Z. (2006). Treatment of ADHD with French maritime pine bark extract, Pycnogenol®. European Child & Adolescent Psychiatry, 15(6), 329–335. https://doi.org/10.1007/s00787-006-0538-3

Ulke, C., Rullmann, M., Huang, J., Luthardt, J., Becker, G.-A., Patt, M., Meyer, P. M., Tiepolt, S., Hesse, S., Sabri, O., & Strauß, M. (2019). Adult attention-deficit/hyperactivity disorder is associated with reduced norepinephrine transporter availability in right attention networks: a (S,S)-O-[11C]methylreboxetine positron emission tomography study. Translational Psychiatry, 9(1), 301. https://doi.org/10.1038/s41398-019-0619-y

Umehara, M., Ago, Y., Fujita, K., Hiramatsu, N., Takuma, K., & Matsuda, T. (2013). Effects of serotonin–norepinephrine reuptake inhibitors on locomotion and prefrontal monoamine release in spontaneously hypertensive rats. European Journal of Pharmacology, 702(1–3), 250–257. https://doi.org/10.1016/j.ejphar.2013.01.033

Verlaet, A. A. J., Maasakkers, C. M., Hermans, N., & Savelkoul, H. F. J. (2018). Rationale for dietary antioxidant treatment of ADHD. In Nutrients (Vol. 10, Issue 4). MDPI AG. https://doi.org/10.3390/nu10040405

Weisler, R. H. (2005). Safety, efficacy and extended duration of action of mixed amphetamine salts extended-release capsules for the treatment of ADHD. Expert Opinion on Pharmacotherapy, 6(6), 1003–1017. https://doi.org/10.1517/14656566.6.6.1003

Published

08-31-2022

How to Cite

Chew, R. (2022). The Explanation of the dependency of the efficacy of ADHD treatments on the age of the recipient. Journal of Student Research, 11(3). https://doi.org/10.47611/jsrhs.v11i3.3465

Issue

Section

HS Review Articles