Xenotransplantation and its adverse effects on the immunology of the human body and solutions

Authors

  • Chaitanya Krishna Conestoga High School
  • Coach Jo Gifted Gabber

DOI:

https://doi.org/10.47611/jsrhs.v11i4.3419

Keywords:

#xenotransplantation #immunology #solutions

Abstract

The current demand in the U.S. for a transplant far exceeds of what is available. In fact, 22 people die each day because they do not get the necessary organ in time. With the human population growing, this problem will surely continue to get worse, but innovative solutions exist. Xenotransplantation, a method where a non-human organ is transplanted into a human, offers exciting potential like none seen before. An unlimited number of cells, tissues, and organs could be “manufactured” through genetic engineering, and this would truly be able to solve the high demand of organs in the United States. Obviously, tons of hurdles exist. Based on multiple sources, specific effects because of hidden diseases inside the graft, or organ of the animal, can cause damage to the patient which is alarming. Organ rejection is also deeply covered: the several types and what it entails in the body. Analyzing from various sources, the purpose of this research paper is to explain the adverse effects that transplantation can cause and to promote further research and investigation on combating the adversities presented.  

Downloads

Download data is not yet available.

Author Biography

Coach Jo, Gifted Gabber

The 8-week session where the student will conduct research and write a scientific journal guided by Dr. Rajagopal Appavu, Assistant Professor, Vaccine Developer, Senior Data Scientist/Analyst, Toxicologist, and Chemist. After the draft has been approved by Professor, students will be guided to submit their scientific journal. 

References or Bibliography

References

Boneva, R. S. (n.d.). Infectious Disease Issues in Xenotransplantation. PubMed. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC88959/

Cascalho, M. (n.d.). The Immunological Barrier to Xenotransplantation.

Immunity.

Cooper, D. (n.d.). "You cannot stay in the laboratory forever"*: Taking pig kidney xenotransplantation from the laboratory to the clinic. PubMed. https://pubmed.ncbi.nlm.nih.gov/34517284/

Hansen, J. (2022, January 20). The 10-gene pig and other medical science advances enabled UAB's transplant of a pig kidney into a brain-dead human recipient. Retrieved August 8, 2022, from https://www.uab.edu/news/research/item/12567-the-10-gene-pig-and-other-medical-science-advances-enabled-uab-s-transplant-of-a-pig-kidney-into-a-brain-dead-human-recipient

Hryhorowicz, M. (n.d.). Application of Genetically Engineered Pigs in Biomedical Research. MDPI. https://www.mdpi.com/2073-4425/11/6/670/htm

Lu, T. (n.d.). Xenotransplantation: Current Status in Preclinical Research. Frontiers in Immunology. https://www.frontiersin.org/articles/10.3389/fimmu.2019.03060/full

Montgomery, R. A. (n.d.). Results of Two Cases of Pig-to-Human Kidney Xenotransplantation. New England Journal of Medicine. https://www.nejm.org/doi/10.1056/NEJMoa2120238

Progress in Xenotransplantation Opens Door to New Supply of Critically Needed Organs. (n.d.). NYU Langone Health. https://nyulangone.org/news/progress-xenotransplantation-opens-door-new-supply-critically-needed-organs

Samstein, B. (n.d.). Physiologic and Immunologic Hurdles to Xenotransplantation. Journal of the American Society of Nephrology. https://jasn.asnjournals.org/content/12/1/182

Vanholder, R. (n.d.). Problems and Solutions for artificial kidney. PubMed. https://pubmed.ncbi.nlm.nih.gov/11258583/

Wijkstrom, M. (n.d.). RENAL XENOTRANSPLANTATION: EXPERIMENTAL PROGRESS AND CLINICAL PROSPECTS. PubMed. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357451/#:~:text=Xenotransplantation%2C%20in%20the%20form%20of,deceased%20and%20living%20human%20donors.

Published

11-30-2022

How to Cite

Krishna, C., & Kethar, J. (2022). Xenotransplantation and its adverse effects on the immunology of the human body and solutions. Journal of Student Research, 11(4). https://doi.org/10.47611/jsrhs.v11i4.3419

Issue

Section

HS Research Articles