Should pharmaceutical scientists use liposomes or micelles as a means for drug delivery?
DOI:
https://doi.org/10.47611/jsrhs.v11i4.3415Keywords:
#DrugDelivery, #Liposomes, #Micelles, #Nanotechnology, #Oncology, #AntineoplasticAbstract
Nanotechnology is the manipulation of matter on a near-atomic scale to produce structures, machines, and devices. Nanotechnology is being used as a method to deliver drugs to combat cancer due to current, artificial systems producing harmful side effects. In this, two main systems stand out: liposomes and micelles. This paper compares the two systems to decide whether one system is more capable and should currently be used in drug deliveries. This paper will look at the structure of liposomes and micelles, clinical studies, and issues that have been noted. It was found that liposomes have a higher carrying capacity and can carry multiple types of drugs. In clinical trials, liposomes were found to be just as effective as current systems. However, they are known to have premature drug releases as well as being difficult to load. Micelles were found to be smaller, making them easier to enter the body. They are also easier to manufacture. In clinical studies, they were found to be just as effective as current systems. However, micelles are not as flexible, have a smaller volume, and much less stable than liposomes. Through compiling the advantages and disadvantages of both of these systems, it was found that overall, liposomes were a better system for drug delivery.
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Almeida, B., Nag, O. K., Rogers, K. E., & Delehanty, J. B. (2020). Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules, 25(23). https://doi.org/10.3390/molecules25235672
Aronson, J.K. (2016). Cremophor. Meyler's Side Effects of Drugs (Sixteenth Edition). https://doi.org/10.1016/B978-0-444-53717-1.00558-8
Hofferberth, S. C., Grinstaff, M. W., & Colson, Y. L. (2016). Nanotechnology applications in thoracic surgery. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 50(1), 6–16. https://doi.org/10.1093/ejcts/ezw002
Huang, S. T., Wang, Y. P., Chen, Y. H., Lin, C. T., Li, W. S., & Wu, H. C. (2018). Liposomal paclitaxel induces fewer hematopoietic and cardiovascular complications than bioequivalent doses of Taxol. International journal of oncology, 53(3), 1105–1117. https://doi.org/10.3892/ijo.2018.4449
Langridge, T. D., & Gemeinhart, R. A. (2020). Toward understanding polymer micelle stability: Density ultracentrifugation offers insight into polymer micelle stability in human fluids. Journal of controlled release : official journal of the Controlled Release Society, 319, 157–167. https://doi.org/10.1016/j.jconrel.2019.12.038
Lee, S. W., Kim, Y. M., Cho, C. H., Kim, Y. T., Kim, S. M., Hur, S. Y., Kim, J. H., Kim, B. G., Kim, S. C., Ryu, H. S., & Kang, S. B. (2018). An Open-Label, Randomized, Parallel, Phase II Trial to Evaluate the Efficacy and Safety of a Cremophor-Free Polymeric Micelle Formulation of Paclitaxel as First-Line Treatment for Ovarian Cancer: A Korean Gynecologic Oncology Group Study (KGOG-3021). Cancer research and treatment, 50(1), 195–203. https://doi.org/10.4143/crt.2016.376
Pauli, G., Tang, W. L., & Li, S. D. (2019). Development and Characterization of the Solvent-Assisted Active Loading Technology (SALT) for Liposomal Loading of Poorly Water-Soluble Compounds. Pharmaceutics, 11(9), 465. https://doi.org/10.3390/pharmaceutics11090465
Sercombe, L., Veerati, T., Moheimani, F., Wu, S. Y., Sood, A. K., & Hua, S. (2015). Advances and Challenges of Liposome Assisted Drug Delivery. Frontiers in pharmacology, 6, 286. https://doi.org/10.3389/fphar.2015.00286
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