The Effects of Genetics and Psychosocial Stress on War-Affected Youth

Abstract

The atrocities of war have a negative impact on those who must witness them. Syrian refugees have gone to Jordan to escape the civil war in their home country. The genetics of the youngest among the refugees plays a role in the development of mental illnesses. The importance of studying the effect of psychosocial stress and genetics on war-affected youth can be seen today when many children are being uprooted from their homes in Ukraine. This study was done using a case-control study. To get DNA, a gender-balanced group of 417 Syrian refugees and 306 Jodanian non-refugees provided buccal samples to the researchers. The male participants were exposed to more traumatic events, but the female participants had higher rates of perceived stress, insecurity, depression and anxiety, and post-traumatic stress disorder symptoms. The serotonin transporter  5-HTTLPR and the protein-coding gene COMT were found to play a role in the response to trauma. 5-HTTLPR was found to be associated with human insecurity and perceived stress. COMT was found to be associated with CRIES-8, also known as PTSD. The results of this study can be used in many ways. They can be used to know which mental health resources should be allocated to those uprooted by wars and the results can be used to advance the study of human behavior.