A Review of Extraction and Detection of Ricin from Castor Plant and the Effect of Ricin on Humans
DOI:
https://doi.org/10.47611/jsrhs.v11i3.2751Keywords:
ricin, ricin extraction, ricin detection, effect of ricin, ricin from castor plant, benefits of ricinAbstract
Ricin is a ribosome inactivating protein produced within the seeds of the castor oil plant (Ricinus communis). Ricin can be extracted from the mash of crushed castor seeds using different procedures. Ricin has 2 chains, the A chain and the B chain. It is extremely potent to mammals, being able to kill 1500 cells per minute in small doses. Castor bean plants are grown as an ornamental plant and are found in most households in parks around India, eastern Africa, and the south-eastern Mediterranean Basin. Methods of detection for ricin have been found, but not one that takes into account its presence in biological fluids. Ricin has also been found to be an immunotoxin against cancer, and it could be used as a medication in the future.
Downloads
References or Bibliography
Arizona Department of Health Services. (2004). RICIN bioterrorism agent profiles for health care workers. http://azdhs.net/documents/preparedness/emergency-preparedness/zebra-manual/zm-s5-ricin.pdf
Albert Einstein College of Medicine. (2009, April 13). Bioterrorism: Fast And Sensitive Way To Detect Ricin. ScienceDaily. Retrieved May 14, 2022 from www.sciencedaily.com/releases/2009/04/090408104538.htmDoan, Leah G. (2004).
CDC Ricin | Diagnosis & Laboratory Guidance for Clinicians. (2018). Center of Disease Control and Prevention. https://emergency.cdc.gov/agent/ricin/clinicians/diagnosis.asp
Doan, L. G. (2004). Ricin: Mechanism of Toxicity, Clinical Manifestations, and Vaccine Development. A Review. Journal of Toxicology: Clinical Toxicology, 42(2), 201–208. https://doi.org/10.1081/clt-120030945
Field, C. W. (1910). A STUDY OF AN EXTREMELY PURE PREPARATION OF RICIN. Journal of Experimental Medicine, 12(4), 551–555. https://doi.org/10.1084/jem.12.4.551
Johnson, R. C., Lemire, S. W., Woolfitt, A. R., Ospina, M., Preston, K. P., Olson, C. T., & Barr, J. R. (2005). Quantification of Ricinine in Rat and Human Urine: A Biomarker for Ricin Exposure. Journal of Analytical Toxicology, 29(3), 149–155. https://doi.org/10.1093/jat/29.3.149
Kesteven, S. (2021, May 4). How writer Georgi Markov was assassinated with a poison-laced umbrella. ABC News. https://www.abc.net.au/news/2021-05-04/gerogi-markov-bulgarian-dissident-umbrella-assassination/100084600
Moshiri, M., Hamid, F., & Etemad, L. (2016). Ricin Toxicity: Clinical and Molecular Aspects. Reports of biochemistry & molecular biology, 4(2), 60–65.
Nick Verougstraete, Dries Helsloot, Christa Deprez, Olivier Heylen, Isabelle Casier, Kathleen Croes, Lethal Injection of a Castor Bean Extract: Ricinine Quantification as a Marker for Ricin Exposure Using a Validated LC–MS/MS Method, Journal of Analytical Toxicology, Volume 43, Issue 3, April 2019, Pages e1–e5, https://doi.org/10.1093/jat/bky100
Ngo, T., Nguyen, T., Bui, D., Hoang, N., & Nguyen, T. (2016). Effects of ricin extracted from seeds of the castor bean (ricinus communis) on cytotoxicity and tumorigenesis of melanoma cells. Biomedical Research and Therapy, 3(05), 633-644. Retrieved from http://www.bmrat.org/index.php/BMRAT/article/view/97
Rocha, A. J., de Oliveira Barsottini, M. R., & da Rocha, S. L. (2019). Selection and validation of castor bean (Ricinus communis) reference genes for quantitative PCR (RT-qPCR) in developing and germinating seeds and expression pattern of four ricin-family genes. Gene Expression Patterns, 34, 119072. https://doi.org/10.1016/j.gep.2019.119072
Sousa, R.B.; Lima, K.S.C.; Santos, C.G.M.; França, T.C.C.; Nepovimova, E.; Kuca, K.; Dornelas, M.R.; Lima, A.L.S. A New Method for Extraction and Analysis of Ricin Samples through MALDI-TOF-MS/MS. Toxins 2019, 11, 201. https://doi.org/10.3390/toxins11040201
Ricinus communis (BIS-Fogo) ·. (n.d.). iNaturalist. https://www.inaturalist.org/guide_taxa/495159
Published
How to Cite
Issue
Section
Copyright (c) 2022 Akshay Shankar; Kumar Joshi
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Copyright holder(s) granted JSR a perpetual, non-exclusive license to distriute & display this article.