Discussion of melittin in cardiovascular treatments

Authors

  • Gaurav Ramasani
  • Coach Jo
  • Dr. Raj

DOI:

https://doi.org/10.47611/jsrhs.v11i2.2555

Keywords:

Melittin, Cardiology, Myocarditis, Honey bee, Bee venom, Cationic peptide

Abstract

In this research paper, we will go over details about melittin peptide, a cationic peptide that was derived from bee venom and is now being used in medicine to cure diseases. We will go over how it was derived, some of its uses in medicine, how it is helping in cardiology, and how it could affect the future of medicine. Recently, there has been a need for a more advanced level of treatment in cardiology, as it is one of the leading causes of death in the United States. That is where melittin is coming into play. Scientists are testing the molecule’s efficacy of resolving issues in the heart by simulating those issues on mice. They then used melittin to see whether it would cure those complications, and they continually repeated those trials. Each time, they were able to see that melittin was able to remove those complications by using methods such as communicating with signaling pathways or even destroying certain molecules by itself.

Downloads

Download data is not yet available.

References or Bibliography

A, M., & C, W. (1980). The effects of honey bee (Apis mellifera L.) venom and two of its constituents, melittin and phospholipase A2, on the cardiovascular system of the rat. PubMed. Retrieved January 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/7210027/

Applications and evolution of melittin, the quintessential membrane active peptide. (2021, November). PubMed. Retrieved January 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/34543656/

Astragalus polysaccharide from Astragalus Melittin ameliorates inflammation via suppressing the activation of TLR-4/NF-κB p65 signal pathway and protects mice from CVB3-induced virus myocarditis. (2019, April 1). PubMed. Retrieved January 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/30586589/

Bitar, M. S. (2012, July 1). The GSK-3β/Fyn/Nrf2 pathway in fibroblasts and wounds of type 2 diabetes. NCBI. Retrieved January 9, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609099/

Comparative Study of Antimicrobial Properties of Bee Venom Extracts and Melittins of Honey Bees. (2021, December 8). antibiotics, 14.

Conformations and Dynamic Transitions of a Melittin Derivative That Forms Macromolecule-Sized Pores in Lipid Bilayers. (2018, June 22). Langmuir, 7. https://pubs.acs.org/doi/abs/10.1021/acs.langmuir.8b00804

Erturk, M. (2006, June). The role of the central thromboxane A2 in cardiovascular effects of a phospholipase A2 activator melittin administrated intracerebroventricularly in normotensive conscious rats. PubMed. Retrieved January 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/16524625/

Figure 2. (n.d.). Retrieved January 18, 2022, from https://www.genscript.com/peptide/RP10290-Melittin.html

Heart Disease Facts | cdc.gov. (2021, September 27). CDC. Retrieved January 9, 2022, from https://www.cdc.gov/heartdisease/facts.htm

Hong, J., Lu, X., Deng, Z., Xiao, S., Yuan, B., Yang, K., & Dosio, F. (2019, May 7). How Melittin Inserts into Cell Membrane: Conformational Changes, Inter-Peptide Cooperation, and Disturbance on the Membrane. NCBI. Retrieved January 9, 2022, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539814/

Hong, T. (2007, August). Melittin, a major bioactive component of bee venom toxin, inhibits PDGF receptor beta-tyrosine phosphorylation and downstream intracellular signal transduction in rat aortic vascular smooth muscle cells. PubMed. Retrieved January 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/17654254/

How Melittin Inserts into Cell Membrane: Conformational Changes, Inter-Peptide Cooperation, and Disturbance on the Membrane. (n.d.). MDPI. Retrieved January 16, 2022, from https://www.mdpi.com/1420-3049/24/9/1775/htm

Melittin = 85 HPLC 20449-79-0. (n.d.). Sigma-Aldrich. Retrieved January 9, 2022, from https://www.sigmaaldrich.com/US/en/product/sigma/m2272

Melittin ameliorates CVB3-induced myocarditis via activation of the HDAC2-mediated GSK-3β/Nrf2/ARE signaling pathway. (2016, November 4). PubMed. Retrieved January 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/27693786/

Melittin has an inhibitory effect on TNF-α-induced migration of human aortic smooth muscle cells by blocking the MMP-9 expression. (2012, November). PubMed. Retrieved January 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/22926441/

NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis. (2016, December 14). PubMed. Retrieved January 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/27986445/

Oršolić, N. (2012, January). Bee venom in cancer therapy. PubMed. Retrieved January 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/22109081/

Pak, C. (2013, September). Effects of cosmetics containing purified honeybee (Apis mellifera L.) venom on acne vulgaris. PubMed. Retrieved January 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/24063779/

Savci, V. (2007, December). Cardiovascular effects of centrally injected melittin in hemorrhaged hypotensive rats: the investigation of peripheral mechanisms. PubMed. Retrieved January 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/17897713/

Savci, V. (2009, December). Cardiovascular effect of peripheral injected melittin in normotensive conscious rats: Mediation of the central cholinergic system. PubMed. Retrieved January 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/19910175/

Seymour, L. (2001, December 14). Melittin enables efficient vesicular escape and enhanced nuclear access of nonviral gene delivery vectors. PubMed. Retrieved January 9, 2022, from https://pubmed.ncbi.nlm.nih.gov/11600500/

Published

05-31-2022

How to Cite

Ramasani, G., Kethar, J., & Appavu, R. (2022). Discussion of melittin in cardiovascular treatments . Journal of Student Research, 11(2). https://doi.org/10.47611/jsrhs.v11i2.2555

Issue

Section

HS Review Articles