Nanophotonics: An Emerging and Promising Approach for COVID-19 Diagnostic Technology
DOI:
https://doi.org/10.47611/jsrhs.v11i1.2475Keywords:
nanophotonics, ring resonator, covid-19, coronavirus, diagnosis, diagnostic technology, pandemic, virus, pcr, polymerase chain reaction, biosensor, anitbody, antigenAbstract
The public health crisis initiated by the emergence of the COVID-19 pandemic emphasizes the need for rapid and accurate diagnostic tests to monitor large populations through community mass testing. Many testing techniques have been implemented to prevent disease spread, critical to pandemic control. Polymerase chain reaction (PCR) tests for detecting viral RNA and immunoassay tests for detecting SARS-CoV-2 antibodies are currently used to diagnose COVID-19. PCR tests are time-consuming, with a 24–48 hours turnaround time. Samples undergoing PCR detection must also be sent to a laboratory to be processed by highly specialized workers, preventing a point-of-care diagnosis from being provided. Popular immunoassay tests have drawbacks as well. Enzyme-linked immunosorbent assays (ELISAs) are extremely labor-intensive and expensive, whereas lateral flow assays (LFAs) are primarily used for antigen detection. In this work, we propose a photonic SARS-CoV-2 detection method based on a ring resonator. We calculate the sensor performance using the finite-difference eigenmode (FDE) method. The sensor sensitivity in ring resonator resonance frequency is 29 nm/RIU, with an intrinsic detection level (iLOD) of 6.89 × 10-5 RIU. We envision ring resonator-based lab-on-chip devices being widely used for applications such as early diagnosis, with the added benefit of being ultra-compact and easily handled by non-specialists.
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Stambaugh, A., Parks, J. W., Stott, M. A., Meena, G. G., Hawkins, A. R., & Schmidt, H. (2021). Optofluidic multiplex detection of single SARS-COV-2 and influenza A antigens using a novel bright fluorescent probe assay. Proceedings of the National Academy of Sciences, 118(20). https://doi.org/10.1073/pnas.2103480118
Higgins, V., Sohaei, D., Diamandis, E. P., & Prassas, I. (2020). COVID-19: from an acute to chronic disease? Potential long-term health consequences. Critical Reviews in Clinical Laboratory Sciences, 58(5), 297–310. https://doi.org/10.1080/10408363.2020.1860895
Murad, D., Chandrasekaran, S., Pillai, A., Garner, O. B., & Denny, C. T. (2021). SARS-CoV-2 Infection Detection by PCR and Serologic Testing in Clinical Practice. Journal of Clinical Microbiology, 59(7). https://doi.org/10.1128/jcm.00431-21
Pisanic, N., Randad, P. R., Kruczynski, K., Manabe, Y. C., Thomas, D. L., Pekosz, A., Klein, S. L., Betenbaugh, M. J., Clarke, W. A., Laeyendecker, O., Caturegli, P. P., Larman, H. B., Detrick, B., Fairley, J. K., Sherman, A. C., Rouphael, N., Edupuganti, S., Granger, D. A., Granger, S. W., . . . Heaney, C. D. (2020). COVID-19 Serology at Population Scale: SARS-CoV-2-Specific Antibody Responses in Saliva. Journal of Clinical Microbiology, 59(1). https://doi.org/10.1128/jcm.02204-20
West, R., Kobokovich, A., Connell, N., & Gronvall, G. K. (2021). COVID-19 Antibody Tests: A Valuable Public Health Tool with Limited Relevance to Individuals. Trends in Microbiology, 29(3), 214–223. https://doi.org/10.1016/j.tim.2020.11.002
Shen, X., Wang, J., Li, J., He, A., Liu, H., & Ma, X. (2021). Field Validation of a Rapid Recombinase Aided Amplification Assay for SARS-CoV-2 RNA at Customs — Zhejiang Province, China, January 2021. China CDC Weekly, 3(46), 973–976. https://doi.org/10.46234/ccdcw2021.236
Aschenbrenner, D. S. (2021). Another Monoclonal Antibody Granted EUA to treat COVID-19. AJN, American Journal of Nursing, 121(8), 22. https://doi.org/10.1097/01.naj.0000767788.97481.65
Haddadpour, A., & Yi, Y. (2010). Metallic nanoparticle on micro ring resonator for bio optical detection and sensing. Biomedical Optics Express, 1(2), 378. https://doi.org/10.1364/boe.1.000378
Sarkaleh, A. K., Lahijani, B. V., Saberkari, H., & Esmaeeli, A. (2017). Optical Ring Resonators: A Platform for Biological Sensing Applications. Journal of medical signals and sensors, 7(3), 185–191.
Castelló-Pedrero, L., Gómez-Gómez, M. I., García-Rupérez, J., Griol, A., & Martínez, A. (2021). Performance improvement of a silicon nitride ring resonator biosensor operated in the TM mode at 1310 nm. Biomedical Optics Express, 12(11), 7244. https://doi.org/10.1364/boe.437823
Schmidt, S., Flueckiger, J., Wu, W., Grist, S. M., Talebi Fard, S., Donzella, V., Khumwan, P., Thompson, E. R., Wang, Q., Kulik, P., Wang, X., Sherwali, A., Kirk, J., Cheung, K. C., Chrostowski, L., & Ratner, D. (2014). Improving the performance of silicon photonic rings, disks, and Bragg gratings for use in label-free biosensing. Biosensing and Nanomedicine VII. Published. https://doi.org/10.1117/12.2062389
Steglich, P., Hülsemann, M., Dietzel, B., & Mai, A. (2019). Optical Biosensors Based on Silicon-On-Insulator Ring Resonators: A Review. Molecules, 24(3), 519. https://doi.org/10.3390/molecules24030519
Castelló-Pedrero, L., Gómez-Gómez, M. I., García-Rupérez, J., Griol, A., & Martínez, A. (2021b). Performance improvement of a silicon nitride ring resonator biosensor operated in the TM mode at 1310 nm. Biomedical Optics Express, 12(11), 7244. https://doi.org/10.1364/boe.437823
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Copyright (c) 2022 Annmaria Antony, Eileen Chen, Shreya Kakhandiki; Ahsan Habib
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