Effect of Antacid Concentration on Acetaminophen-Alginate Sphere Diffusion in a Model Gastric System
DOI:
https://doi.org/10.47611/jsrhs.v10i1.1335Keywords:
Alginate, Acetaminophen, Antacid, Spectrophotometry, SpherificationAbstract
This paper presents a growing awareness for socio-cultural and socio-economic factors in medical and pharmaceutical treatments through a review of the current literature, and a concurrent need to produce a cheap and vegetarian alternative to current capsules. It was hypothesized that increasing the concentration of antacid would increase the rate of diffusion of the contents of an acetaminophen-alginate sphere due to the neutralization of pH between stomach acid and the antacid. The methodology employed prepared these spheres with reverse spherification, tested them via spectrophotometry in a model stomach system, and analyzed the data using the Beer-Lambert Law. Finally, it was found that increasing antacid concentration has a direct, yet exponentially decreasing relationship with the rate of diffusion, therefore the hypothesis was only partially correct.
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